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Table 2 Time to UTIs and lengths of stay according to presence of bacteraemia and carbapenem resistance

From: Burden of illness in US hospitals due to carbapenem-resistant Gram-negative urinary tract infections in patients with or without bacteraemia

Characteristic

Overall, N = 47,496

With bacteraemia, n = 11,629

Without bacteraemia, n = 35,867

CR, n = 2076

CS, n = 45,420

P value

CR, n = 201

CS, n = 11,428

P value

CR, n = 1875

CS, n = 33,992

P value

Time between admission and index culture, days

Mean (SD)

3.6 (10.9)

2.1 (9.3)

< 0.001

5.1 (13.8)

1.5 (3.9)

< 0.001

3.5 (10.5)

2.3 (10.5)

< 0.001

Median (Q1–Q3)

1 (1.0–2.0)

1 (1.0–1.0)

< 0.001

1 (1.0–1.0)

1 (1.0–1.0)

< 0.001

1 (1.0–2.0)

1 (1.0–1.0)

< 0.001

1 day prior to admission, n (%)

186 (9.0)

4285 (9.4)

< 0.001

23 (11.4)

1256 (11.0)

< 0.001

163 (8.7)

3029 (8.9)

< 0.001

Same day as admission, n (%)

1300 (62.6)

31,927 (70.3)

 

139 (69.2)

9409 (82.3)

 

1161 (61.9)

22,518 (66.2)

 

Overall LOSa, days

Mean (SD)

12.5 (23.8)

9.3 (23.0)

< 0.001

18.0 (25.0)

9.1 (11.8)

< 0.001

11.9 (23.6)

9.4 (25.7)

< 0.001

Median (Q1–Q3)

8 (5.0–12.0)

6 (4.0–10.0)

< 0.001

9 (6.0–16.0)

7 (5.0–10.0)

< 0.001

8 (5.0–12.0)

6 (4.0–10.0)

< 0.001

1–2, n (%)

57 (2.7)

1683 (3.7)

< 0.001

5 (2.5)

340 (3.0)

< 0.001

52 (2.8)

1343 (4.0)

< 0.001

3–6, n (%)

729 (35.1)

21,109 (46.5)

 

47 (23.4)

5256 (46.0)

 

682 (36.4)

15,853 (46.6)

 

7–10, n (%)

622 (30.0)

11,922 (26.2)

 

66 (32.8)

3305 (28.9)

 

556 (29.7)

8617 (25.4)

 

11–15, n (%)

303 (14.6)

5313 (11.7)

 

32 (15.9)

1355 (11.9)

 

271 (14.5)

3958 (11.6)

 

16+, n (%)

365 (17.6)

5393 (11.9)

 

51 (25.4)

1172 (10.3)

 

314 (16.7)

4221 (12.4)

 

Infection-associated LOSb, days

Mean (SD)

9.9 (16.3)

8.2 (15.3)

< 0.001

13.9 (16.1)

8.6 (9.9)

< 0.001

9.5 (16.3)

8.1 (16.7)

< 0.001

Median (Q1–Q3)

7 (5.0–11.0)

6 (4.0–9.0)

< 0.001

9 (6.0–14.0)

7 (5.0–10.0)

< 0.001

7 (5.0–10.0)

6 (4.0–9.0)

< 0.001

1–2, n (%)

87 (4.2)

1669 (3.7)

< 0.001

6 (3.0)

314 (2.7)

< 0.001

81 (4.3)

1355 (4.0)

< 0.001

3–6, n (%)

812 (39.1)

22,924 (50.5)

 

45 (22.4)

5327 (46.6)

 

767 (40.9)

17,597 (51.8)

 

7–10, n (%)

639 (30.8)

12,125 (26.7)

 

72 (35.8)

3435 (30.1)

 

567 (30.2)

8690 (25.6)

 

11–15, n (%)

299 (14.4)

4951 (10.9)

 

36 (17.9)

1349 (11.8)

 

263 (14.0)

3602 (10.6)

 

16+, n (%)

239 (11.5)

3751 (8.3)

 

42 (20.9)

1003 (8.8)

 

197 (10.5)

2748 (8.1)

 

ICU occurred during index hospitalisation, n (%)

670 (32.3)

15,737 (34.7)

0.026

114 (56.7)

5156 (45.1)

0.001

556 (29.7)

10,581 (31.1)

0.179

ICU LOS, days

Mean (SD)

9.0 (21.8)

5.8 (17.7)

< 0.001

14.4 (28.0)

5.2 (12.0)

0.001

7.9 (20.1)

6.0 (19.9)

0.034

Median (Q1–Q3)

3 (1.0–8.0)

3 (1.0–6.0)

0.100

3 (1.0–10.0)

3 (1.0–5.0)

0.172

3 (1.0–7.5)

3 (1.0–7.0)

0.405

Infection-associated ICU stay, n (%)

520 (25.1)

12,940 (28.5)

0.001

100 (49.8)

4713 (41.2)

0.015

420 (22.4)

8227 (24.2)

0.076

ICU at index culture, n (%)

413 (19.9)

9874 (21.7)

0.046

76 (37.8)

3587 (31.4)

0.052

337 (18.0)

6287 (18.5)

0.571

Infection-associated ICU LOSc, days

Mean (SD)

6.5 (14.6)

4.9 (10.1)

0.013

9.2 (17)

4.8 (10.2)

0.011

5.9 (13.9)

5.0 (10.1)

0.195

Median (Q1–Q3)

3 (1.0–7.0)

3 (1.0–6.0)

0.173

3 (1.0–8.5)

3 (1.0–5.0)

0.373

3 (1.0–6.0)

3 (1.0–6.0)

0.381

  1. Patients with index culture taken before the admission or after discharge were excluded from the analyses
  2. CR Carbapenem resistant, CS Carbapenem susceptible, ICU Intensive care unit, LOS Length of stay, SD Standard deviation, UTI Urinary tract infection
  3. aOverall LOS: number of days from admission to discharge
  4. bInfection-associated LOS: number of days from index culture date to discharge
  5. cInfection-associated ICU LOS: if a positive culture was obtained within 2 days of ICU admission, the entire ICU LOS was used; if the culture was obtained during ICU stay, the LOS was taken as the number of days from the index culture to discharge from the ICU