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Table 2 Time to UTIs and lengths of stay according to presence of bacteraemia and carbapenem resistance

From: Burden of illness in US hospitals due to carbapenem-resistant Gram-negative urinary tract infections in patients with or without bacteraemia

Characteristic Overall, N = 47,496 With bacteraemia, n = 11,629 Without bacteraemia, n = 35,867
CR, n = 2076 CS, n = 45,420 P value CR, n = 201 CS, n = 11,428 P value CR, n = 1875 CS, n = 33,992 P value
Time between admission and index culture, days
Mean (SD) 3.6 (10.9) 2.1 (9.3) < 0.001 5.1 (13.8) 1.5 (3.9) < 0.001 3.5 (10.5) 2.3 (10.5) < 0.001
Median (Q1–Q3) 1 (1.0–2.0) 1 (1.0–1.0) < 0.001 1 (1.0–1.0) 1 (1.0–1.0) < 0.001 1 (1.0–2.0) 1 (1.0–1.0) < 0.001
1 day prior to admission, n (%) 186 (9.0) 4285 (9.4) < 0.001 23 (11.4) 1256 (11.0) < 0.001 163 (8.7) 3029 (8.9) < 0.001
Same day as admission, n (%) 1300 (62.6) 31,927 (70.3)   139 (69.2) 9409 (82.3)   1161 (61.9) 22,518 (66.2)  
Overall LOSa, days
Mean (SD) 12.5 (23.8) 9.3 (23.0) < 0.001 18.0 (25.0) 9.1 (11.8) < 0.001 11.9 (23.6) 9.4 (25.7) < 0.001
Median (Q1–Q3) 8 (5.0–12.0) 6 (4.0–10.0) < 0.001 9 (6.0–16.0) 7 (5.0–10.0) < 0.001 8 (5.0–12.0) 6 (4.0–10.0) < 0.001
1–2, n (%) 57 (2.7) 1683 (3.7) < 0.001 5 (2.5) 340 (3.0) < 0.001 52 (2.8) 1343 (4.0) < 0.001
3–6, n (%) 729 (35.1) 21,109 (46.5)   47 (23.4) 5256 (46.0)   682 (36.4) 15,853 (46.6)  
7–10, n (%) 622 (30.0) 11,922 (26.2)   66 (32.8) 3305 (28.9)   556 (29.7) 8617 (25.4)  
11–15, n (%) 303 (14.6) 5313 (11.7)   32 (15.9) 1355 (11.9)   271 (14.5) 3958 (11.6)  
16+, n (%) 365 (17.6) 5393 (11.9)   51 (25.4) 1172 (10.3)   314 (16.7) 4221 (12.4)  
Infection-associated LOSb, days
Mean (SD) 9.9 (16.3) 8.2 (15.3) < 0.001 13.9 (16.1) 8.6 (9.9) < 0.001 9.5 (16.3) 8.1 (16.7) < 0.001
Median (Q1–Q3) 7 (5.0–11.0) 6 (4.0–9.0) < 0.001 9 (6.0–14.0) 7 (5.0–10.0) < 0.001 7 (5.0–10.0) 6 (4.0–9.0) < 0.001
1–2, n (%) 87 (4.2) 1669 (3.7) < 0.001 6 (3.0) 314 (2.7) < 0.001 81 (4.3) 1355 (4.0) < 0.001
3–6, n (%) 812 (39.1) 22,924 (50.5)   45 (22.4) 5327 (46.6)   767 (40.9) 17,597 (51.8)  
7–10, n (%) 639 (30.8) 12,125 (26.7)   72 (35.8) 3435 (30.1)   567 (30.2) 8690 (25.6)  
11–15, n (%) 299 (14.4) 4951 (10.9)   36 (17.9) 1349 (11.8)   263 (14.0) 3602 (10.6)  
16+, n (%) 239 (11.5) 3751 (8.3)   42 (20.9) 1003 (8.8)   197 (10.5) 2748 (8.1)  
ICU occurred during index hospitalisation, n (%) 670 (32.3) 15,737 (34.7) 0.026 114 (56.7) 5156 (45.1) 0.001 556 (29.7) 10,581 (31.1) 0.179
ICU LOS, days
Mean (SD) 9.0 (21.8) 5.8 (17.7) < 0.001 14.4 (28.0) 5.2 (12.0) 0.001 7.9 (20.1) 6.0 (19.9) 0.034
Median (Q1–Q3) 3 (1.0–8.0) 3 (1.0–6.0) 0.100 3 (1.0–10.0) 3 (1.0–5.0) 0.172 3 (1.0–7.5) 3 (1.0–7.0) 0.405
Infection-associated ICU stay, n (%) 520 (25.1) 12,940 (28.5) 0.001 100 (49.8) 4713 (41.2) 0.015 420 (22.4) 8227 (24.2) 0.076
ICU at index culture, n (%) 413 (19.9) 9874 (21.7) 0.046 76 (37.8) 3587 (31.4) 0.052 337 (18.0) 6287 (18.5) 0.571
Infection-associated ICU LOSc, days
Mean (SD) 6.5 (14.6) 4.9 (10.1) 0.013 9.2 (17) 4.8 (10.2) 0.011 5.9 (13.9) 5.0 (10.1) 0.195
Median (Q1–Q3) 3 (1.0–7.0) 3 (1.0–6.0) 0.173 3 (1.0–8.5) 3 (1.0–5.0) 0.373 3 (1.0–6.0) 3 (1.0–6.0) 0.381
  1. Patients with index culture taken before the admission or after discharge were excluded from the analyses
  2. CR Carbapenem resistant, CS Carbapenem susceptible, ICU Intensive care unit, LOS Length of stay, SD Standard deviation, UTI Urinary tract infection
  3. aOverall LOS: number of days from admission to discharge
  4. bInfection-associated LOS: number of days from index culture date to discharge
  5. cInfection-associated ICU LOS: if a positive culture was obtained within 2 days of ICU admission, the entire ICU LOS was used; if the culture was obtained during ICU stay, the LOS was taken as the number of days from the index culture to discharge from the ICU