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Table 2 Changes of HBV DNA VL (log10 IU/ml) over time assessed by linear mixed effects models for patients treated with TDF vs. untreated

From: Hepatitis B virus (HBV) viral load, liver and renal function in adults treated with tenofovir disoproxil fumarate (TDF) vs. untreated: a retrospective longitudinal UK cohort study

 

Crude model

 

Adjusted for baseline age, gender, ethnicity

 

Coefficient β (95% CI)

p-value

Coefficient β (95% CI)

p-value

(Intercept)

2.783 (2.627, 2.939)

< 0.001

3.476 (3.020, 3.931)

< 0.001

Group

0.162 (− 0.114, 0.437)

0.250

0.123 (− 0.163, 0.409)

0.399

Time

−0.013 (− 0.019, − 0.007)

< 0.001

−0.013 (− 0.019, − 0.007)

< 0.001

Group x Time a

−0.041 (− 0.050, − 0.032)

< 0.001

− 0.041 (− 0.050, − 0.032)

< 0.001

  1. a x indicates the interaction between group and follow-up time. Group = {0,1}, where 0 indicates untreated, 1 indicates TDF. A log transformation was applied to the dependent variable (HBV DNA) due to nonlinearity. CI confidence interval; TDF Tenofovir disoproxil fumarate; VL viral load