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Table 2 Changes of HBV DNA VL (log10 IU/ml) over time assessed by linear mixed effects models for patients treated with TDF vs. untreated

From: Hepatitis B virus (HBV) viral load, liver and renal function in adults treated with tenofovir disoproxil fumarate (TDF) vs. untreated: a retrospective longitudinal UK cohort study

  Crude model   Adjusted for baseline age, gender, ethnicity
  Coefficient β (95% CI) p-value Coefficient β (95% CI) p-value
(Intercept) 2.783 (2.627, 2.939) < 0.001 3.476 (3.020, 3.931) < 0.001
Group 0.162 (− 0.114, 0.437) 0.250 0.123 (− 0.163, 0.409) 0.399
Time −0.013 (− 0.019, − 0.007) < 0.001 −0.013 (− 0.019, − 0.007) < 0.001
Group x Time a −0.041 (− 0.050, − 0.032) < 0.001 − 0.041 (− 0.050, − 0.032) < 0.001
  1. a x indicates the interaction between group and follow-up time. Group = {0,1}, where 0 indicates untreated, 1 indicates TDF. A log transformation was applied to the dependent variable (HBV DNA) due to nonlinearity. CI confidence interval; TDF Tenofovir disoproxil fumarate; VL viral load