Skip to main content

Table 1 Baseline characteristics of adults with chronic hepatitis B virus infection (Tenofovir disoproxil fumarate vs. untreated)

From: Hepatitis B virus (HBV) viral load, liver and renal function in adults treated with tenofovir disoproxil fumarate (TDF) vs. untreated: a retrospective longitudinal UK cohort study

  TDF group Untreated group p-value
  (n = 60) (n = 146)  
Follow-up duration (years) 3.8 [2.6, 4.6] 3.0 [1.9, 4.9] 0.176
Age (years) 39 [33, 48] 35 [30, 40] 0.004
Age > 60 (years) (%) 4 (6.7) 5 (3.4) 0.510
Gender (%)
 Female 20 (33.3) 71 (48.6) 0.064
 Male 38 (63.3) 68 (46.6) 0.042
 Unreported 2 (3.3) 7 (4.8) 1
Ethnicity (%) §
 Asian 33 (55.0) 33 (22.6) < 0.001
 Black 11 (18.3) 31 (21.2) 0.780
 White 9 (15.0) 28 (19.2) 0.610
 Other 4 (6.7) 10 (6.8) 1
 Unreported 3 (5.0) 44 (30.1) < 0.001
HBeAg positive (%) 5 (8.3) 4 (2.7) 0.126
Diabetes (%)
 Yes 2 (3.3) 6 (4.1) 1
 No 25 (41.7) 72 (49.3) 0.398
 Unknown 33 (55.0) 68 (46.6) 0.344
ALT (x ULN) (IU/L) 1.1 [0.7, 1.8] 0.6 [0.4, 0.8] < 0.001
HBV DNA (log10 IU/ml) 4.8 [4.1, 6.1] 2.7 [1.9, 3.5] < 0.001
qHBsAg (log10 IU/ml) 3.0 [3.0, 3.6] 3.0 [3.0, 3.6] 0.425
Liver stiffness (kPa) 7.5 [5.0, 10.0] 5.0 [4.0, 6.0] 0.002
  < 8 kPa 11 (18.3) 69 (47.3) < 0.001
  ≥ 8 kPa and < 14 kPa 9 (15.0) 6 (4.1) 0.015
  ≥ 14 kPa 2 (3.3) 0 (0.0) < 0.001
 Unavailable 38 (63.3) 71 (48.6) 0.077
eGFR (ml/min/1.73m2) # 90 [89, > 90] 90 [87, > 90] 0.613
  ≥ 90 ml/min/1.73m2 29 (48.3) 72 (49.3) 1
 60 ~ 89 ml/min/1.73m2 11 (18.3) 30 (20.5) 0.865
  < 60 ml/min/1.73m2 0 (0) 1 (0.97) 1
 Unavailable 20 (33.3) 43 (29.5) 0.702
Serum creatinine (μmol/l) 72 [57, 80] 73 [57, 83] 0.766
Serum urea (mmol/l) 5 [4, 6] 4 [4, 6] 0.199
Albumin (g/L) 42 [38, 44] 41 [38, 45] 0.861
ALP (IU/L) 114 [63, 163] 96 [63, 150] 0.266
Bilirubin (total) (umol/L) 10 [8, 15] 9 [7, 12] 0.104
Platelet count (×  109/L) 205 [162.5, 240.0] 219 [185.5, 252.2] 0.078
  1. Data are the median [interquartile range] or number (%) unless otherwise indicated. For categorical variables, Fisher's exact test was performed for comparison on cells with small counts (< 5), otherwise Chi-square test was used. For continuous variables, Wilcoxon test was used for comparison due to non-normality. p values < 0.05 were deemed statistically significant, marked in bold. § Ethnicity was originally self-reported by patients according to NHS standard ethnic categories. Diabetes was diagnosed using glycated haemoglobin (HbA1c), an HbA1c of 6.5% or 47.5 mmol/mol is a typical threshold for diagnosing diabetes. Liver stiffness was measured by transient elastography score in kiloPascals (kPa). # For eGFR, if a level was greater than 90 ml/min/1.73m2, it was not quantified by the hospital laboratory system. ALT Alanine aminotransferase; eGFR estimated Glomerular Filtration Rate; ALP Alkaline phosphatase; TDF Tenofovir disoproxil fumarate; qHBsAg quantitative HBsAg level; ULN upper limit of normal