Fig. 1

Longitudinal analysis of HBV DNA VL in chronic HBV patients with TDF treatment vs. without treatment. (A) Distribution of HBV DNA VL at each time point; (B) Stratification of HBV DNA VL at each time point; (C) Kaplan-Meier analysis to estimate the probability of patients with HBV DNA VL > 20 IU/ml in each group over time. In Kaplan-Meier analysis, real dates were used for calculating the time to HBV DNA VL suppressed < 20 IU/ml, rather than the imputed time points and censored subjects were marked on the curve by dots. * p-value < 0.05, ** p-value < 0.01, *** p-value < 0.001, **** p-value < 0.0001. HBV, hepatitis B virus; TDF, Tenofovir disoproxil fumarate; VL, viral load