Prevalence, species distribution and antifungal susceptibility of Candida albicans causing vaginal discharge among symptomatic non-pregnant women of reproductive age at a tertiary care hospital, Vietnam

Table 2 Ranges of MICs, and percentage resistance in 46 C. albicans isolates

Antifungal agents	MIC ranges	MIC₅₀	MIC₉₀	MIC_GM	S (%)	I/SDD (%)	R (%)
Micafungin	≤0.015–0.03	≤0.015	0.015	0.015	100.0	0	0
Caspofungin	≤0.03–0.5	0.06	0.25	0.077	95.65	4.35	0
Amphotericine B	0.5–2	1.0	1.0	0.886	95.65	–	4.35
5-Flucytosine	≤0.12–64	0.12	2.0	0.427	91.30	4.35	4.35
Fluconazole	≤0.12–64	0.12	2.0	0.232	91.30	4.35	4.35
Itraconazole	≤0.03–8	0.06	0.25	0.109	82.61	10.87	6.52
Voriconazole	≤0.015–8	0.015	0.25	0.031	86.95	8.70	4.35
Miconazole	≤0.03–8	0.03	0.12	0.043	100.0	0	0

Note: MIC₅₀: concentration at which 50% of the isolates were inhibited; MIC₉₀: concentration at which 90% of the isolates were inhibited. The breakpoints for antifungal agents used for C. albicans are: MFG (S ≤ 0.25; I/SDD = 0.5; R ≥ 1); CAS (S ≤ 0.25; I/SDD = 0.5; R ≥ 1); AMB (S ≤ 1; R ≥ 2); 5-FC (S ≤ 4; I/SDD = 8–16; R ≥ 32); FCZ (S ≤ 2; I/SDD = 4; R ≥ 8); VCZ (S ≤ 0.12; I/SDD = 0.25–0.5; R ≥ 1), ICZ (S ≤ 0.12; I/SDD = 0.25–0.5; R ≥ 1) and MCZ (S < 8; R ≥ 8)
Abbreviation: S susceptible, I/SDD Intermediate/susceptible dose dependent, R Resistant

ISSN: 1471-2334