Skip to main content

Table 1 Inclusion and exclusion criteria

From: Ticking on Pandora’s box: a prospective case-control study into ‘other’ tick-borne diseases

Cases
 Inclusion criteria:
  • Subjects are ≥16 years old;
  • Subjects report a tick-bite acquired within the last 2 months;
  • Subjects report an objectified (measured rectally, axillary, orally or tympanic) fever (defined as ≥38.0 °C) within the last 4 weeks, developed in the course of 4 weeks after tick-bite;
  • Subjects live or stay in the Netherlands during the course of the study.
 Exclusion criteria:
  • Subjects with evident signs or symptoms of another cause of the fever besides a TBD;
  • Subjects unable to provide informed consent or do not have sufficient proficiency of the Dutch language.
Tick-bite controls (A)
 Inclusion criteria:
  • Subjects are ≥16 years old;
  • Subjects report a tick-bite acquired within the last 2 months;
  • Subjects frequency match to cases by gender, age, province of residence and month of tick-bite acquirement;
  • Subjects live or stay in the Netherlands during the course of the study.
 Exclusion criteria:
  • Subjects develop an objectified (measured rectally, axillary, orally or tympanic) temperature > 37.3 °C within 4 weeks after the tick-bite;
  • Subjects with evident signs or symptoms of a currant infectious disease;
  • Subjects unable to provide informed consent or do not have sufficient proficiency of the Dutch language.
Population background controls (B)
 Inclusion criteria:
  • Subjects are ≥16 years old;
  • Subjects participating in the national serosurvey PIENTER-3 of the National Institute for Public Health and Environment (RIVM) of the Netherlands;
  • Subjects frequency match to cases by gender and age.
 Exclusion criterium:
  • Subjects unable to give informed consent or do not have sufficient proficiency of the Dutch, English, French, Spanish, Arabian, Turkish or Papiamentu language.
Healthy blood donors (C)
 Inclusion criteria:
  • Subjects are ≥18 years old;
  • Subjects presenting as a healthy blood donor at the national blood bank Sanquin;
  • Subjects frequency match to cases by gender, age and province of residence.
 Exclusion criterium:
  • Subjects unable to give informed consent.