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Table 3 Total number of HFMD case reduction in I3* under different coverage scenarios over 1 year

From: The burden of hand, foot, and mouth disease among children under different vaccination scenarios in China: a dynamic modelling study

Bivalent vaccine coverage EV-71 vaccine coverage
0% 10% 30% 50% 80%
Case reduction (%**) NNV*** Case reduction (%) NNV Case reduction (%) NNV Case reduction (%) NNV Case reduction (%) NNV
0% 0(0.0) 123,776(7.6) 77.6 339,672(20.9) 84.8 537,032(33.0) 89.4 797,262(49.1) 96.3
10% 130,639(8.0) 73.5 240,476(14.8) 79.8 446,345(27.5) 86.0 633,389(39.0) 90.9 877,700(54.0) 98.4
30% 357,871(22.0) 80.5 457,647(28.2) 83.9 642,969(39.6) 89.6 808,968(49.8) 94.9 1,021,084(62.8) 103.4
50% 563,164(34.7) 85.2 652,564(40.2) 88.3 816,793(50.3) 94.0 961,374(59.2) 99.9 1,141,319(70.2) 109.3
80% 828,560(51.0) 92.7 901,989(55.5) 95.8 1,034,085(63.6) 102.1 1,146,680(70.6) 108.8 1,280,602(78.8) 119.9
100% 976,602(60.1) 98.3 1,039,339(63.9) 101.6 1,150,320(70.8) 108.5 1,242,653(76.5) 115.9 1,349,720(83.0) 128.0
  1. *I3 indicates the number of EV71 or CVA16 HFMD \( \left({\mathrm{I}}_{\mathrm{h}}^{\mathrm{ec}}\right) \) / only EV71- HFMD \( \left({\mathrm{I}}_{\mathrm{h}}^{\mathrm{e}}\right) \), based on different types of vaccines.
  2. **%: The percentage of the number of HFMD case reduction in I3 based on the initial number with no intervention
  3. ***NNV The number of persons needed to be vaccinated per case reduction