Table 1 Antimicrobial activity against respiratory Enterobacterales isolates by region (ATLAS 2016–2018)

Africa/Middle East

(n = 833)

Amoxicillin-clavulanate

≥64

0.5–≥64

37.0

N/A

63.0

Piperacillin-tazobactam

128

≤0.12–≥256

78.3

5.4

16.3

Aztreonam

64

≤0.015–≥256

65.2

3.8

31.0

Ceftazidime

64

≤0.015–≥256

65.5

4.8

29.7

Ceftazidime-avibactam

0.5

≤0.015–≥256

99.0

N/A

1.0

Cefepime

32

≤0.12–≥64

66.3

4.8

28.9

Imipenem

2

0.06–≥16

89.9

8.0

2.0

Meropenem

0.12

0.015–≥32

96.8

1.0

2.3

Levofloxacin

≥16

0.03–≥16

71.9

8.6

19.4

Colistin (n = 714)^a

0.5

≤0.06–≥16

97.8

N/A

2.2

Amikacin

4

≤0.25–≥128

95.8

N/A

4.2

Tigecycline^b

1

0.03–8

98.6

0.0

1.4

Asia/South Pacific

(n = 2033)

Amoxicillin-clavulanate

≥64

≤0.12–≥64

47.2

N/A

52.8

Piperacillin-tazobactam

128

≤0.12–≥256

76.7

4.7

18.5

Aztreonam

128

≤0.015–≥256

66.9

2.9

30.2

Ceftazidime

128

≤0.015–≥256

65.2

3.3

31.5

Ceftazidime-avibactam

1

≤0.015–≥256

96.9

N/A

3.1

Cefepime

32

≤0.12–≥64

74.0

3.3

22.7

Imipenem

2

0.06–≥16

89.5

6.4

4.1

Meropenem

0.12

0.015–≥32

95.5

1.0

3.4

Levofloxacin

≥16

0.015–≥16

66.5

6.7

26.8

Colistin (n = 1824)^a

1

≤0.06–≥16

95.2

N/A

4.8

Amikacin

4

≤0.25–≥128

94.9

N/A

5.1

Tigecycline^b

1

≤0.015–≥16

97.9

0.0

2.1

Europe

(n = 6006)

Amoxicillin-clavulanate

≥64

0.25–≥64

41.1

N/A

58.9

Piperacillin-tazobactam

128

≤0.12–≥256

75.5

4.7

19.8

Aztreonam

128

≤0.015–≥256

71.3

2.6

26.1

Ceftazidime

128

≤0.015–≥256

70.4

3.9

25.7

Ceftazidime-avibactam

0.5

≤0.015–≥256

98.5

N/A

1.5

Cefepime

32

≤0.12–≥64

76.0

3.8

20.1

Imipenem

2

≤0.03–≥16

86.6

9.0

4.4

Meropenem

0.12

0.008–≥32

95.0

1.3

3.7

Levofloxacin

≥16

0.008–≥16

72.6

4.7

22.7

Colistin (n = 5172)^a

0.5

≤0.06–≥16

96.6

N/A

3.4

Amikacin

8

≤0.25–≥128

94.4

N/A

5.6

Tigecycline^b

1

≤0.015–≥16

98.8

0.0

1.2

Latin America

(n = 1256)

Amoxicillin-clavulanate

≥64

0.5–≥64

42.4

N/A

57.6

Piperacillin-tazobactam

128

≤0.12–≥256

78.5

4.8

16.7

Aztreonam

128

≤0.015–≥256

67.0

2.1

30.9

Ceftazidime

64

≤0.015–≥256

66.4

3.7

29.9

Ceftazidime-avibactam

0.5

≤0.015–≥256

99.6

N/A

0.4

Cefepime

32

≤0.12–≥64

70.8

4.3

24.9

Imipenem

2

0.06–≥16

88.4

6.8

4.8

Meropenem

0.12

0.015–≥32

95.8

1.1

3.1

Levofloxacin

≥16

0.015–≥16

68.5

5.7

25.8

Colistin (n = 1074)^a

0.5

≤0.06–≥16

96.6

N/A

3.4

Amikacin

4

≤0.25–≥128

94.6

N/A

5.4

Tigecycline^b

1

0.06–8

100

0.0

0.0