Table 2 Demographic, clinical and laboratory parameters of the study population

 Female

6 (35.3%)

5 (18.5%)

3 (11.5%)

7 (20.0%)

6 (22.2%)

3.690

0.450

17 (20.7%)

3 (21.4%)

0.004

0.953

 Male

11 (64.7%)

22 (81.5%)

23 (88.5%)

28 (80.0%)

21 (77.8%)

65 (79.3%)

11 (78.6%)

Age, years

36.47 ± 17.14

40.07 ± 13.67

43.62 ± 12.96

44.51 ± 15.09

40.65 ± 13.16

1.419

0.242

41.76 ± 14.34

46.57 ± 16.52

−1.136

0.259

^a Timing, days

7.0 (5.0–7.5)

6.0 (5.0–7.0)

6.0 (5.0–7.0)

6.0 (5.0–8.0)

–

1.036

0.793

7.0 (5.0–8.0)

6.0 (4.5–6.5)

−1.643

0.058

 All patients

10.00 ± 2.15

13.72 ± 3.41

20.42 ± 5.95

17.32 ± 11.81

–

6.771

< 0.001

16.0 (12.0–23.0)

6.0 (1.76–10.5)

−4.999

< 0.001

 Survivors

10.00 ± 2.15

13.72 ± 3.41

20.42 ± 5.95

26.41 ± 7.13

–

34.549

< 0.001

 Acute phase

58.21 (22.84–334.37)

216.13 (63.61–539.01)

171.07 (51.28–458.82)

570.30 (138.37–1088.51)

0.46 (0.18–0.65)

69.128

< 0.001

181.79 (41.14–518.53)

935.04 (258.74–1453.42)

−3.021

0.003

 Convalescent phase

2.52 (1.25–11.19)

11.30 (5.64–26.90)

5.87 (3.14–8.00)

4.92 (2.49–11.34)

56.540

< 0.001

–

–

–

–

WBC, × 10⁹/L

11.60 (7.86–13.34)

11.08 (7.67–16.72)

13.37 (8.91–20.16)

14.95 (9.62–27.72)

–

6.019

0.111

12.49 (8.45–18.15)

33.05 (12.04–46.58)

−2.886

0.004

PLT, ×10⁹/L

58.50 (50.25–104.50)

37.00 (25.50–55.50)

34.00 (22.75–51.50)

26.00 (14.00–54.50)

–

11.966

0.008

39.50 (24.00–58.25)

22.50 (10.25–39.50)

−2.938

0.003

ALB, g/L

31.31 ± 3.96

29.30 ± 4.43

28.22 ± 6.01

27.17 ± 4.67

–

2.008

0.120

28.86 ± 5.06

23.81 ± 8.21

2.227

0.042

ALT, U/L

37.50 (28.75–59.00)

43.00 (28.25–68.75)

53.00 (42.75–88.50)

64.00 (49.00–118.00)

–

8.149

0.043

51.00 (32.00–78.50)

97.00 (55.50–265.50)

−3.081

0.002

AST, U/L

69.50 (47.25–105.50)

81.00 (56.00–112.75)

89.50 (60.50–154.00)

121.00 (69.00–197.00)

–

5.582

0.134

85.00 (59.00–124.00)

260.50 (185.00–825.75)

−4.543

< 0.001

PT, sec

10.90 (10.63–11.70)

11.50 (9.75–12.20)

11.50 (10.60–13.05)

11.50 (10.80–13.20)

–

1.710

0.635

11.50 (10.60–12.40)

15.10 (12.53–21.00)

−3.982

< 0.001

APTT, sec

34.22 ± 5.02

37.17 ± 7.48

41.22 ± 9.77

35.49 ± 8.03

–

2.873

0.042

36.00 (31.90–43.00)

58.50 (41.95–75.20)

−4.341

< 0.001

Fib, g/L

2.97 ± 0.91

2.49 ± 0.72

2.77 ± 1.02

2.26 ± 1.01

–

1.861

0.144

2.62 ± 0.93

1.54 ± 0.76

4.104

< 0.001

BUN, mmol/L

8.86 ± 4.92

14.54 ± 9.06

19.55 ± 11.01

19.78 ± 6.94

–

5.699

0.001

13.97 (7.07–22.99)

13.27 (7.61–29.90)

−0.426

0.670

Cr, μmol/L

112.40 (66.15–213.65)

175.60 (85.50–333.90)

303.10 (122.40–540.15)

431.30 (248.65–533.00)

–

16.075

0.001

216.35 (109.63–481.75)

245.25 (97.10–327.78)

−0.405

0.686