Significant decline of HPV 6 infection and genital warts despite low HPV vaccination coverage in young women in Germany: a long-term prospective, cohort data analysis

Table 3 Life-time risk (sum of pre-existing and incident cases) of developing genital warts in WOLVES cohorts (2010–2015). Statistical comparisons are shown for cohorts 1 versus 3, cohorts 2 versus 4, and participants analyzed in 2010 (cohorts 1 + 2) versus those analyzed in 2015 (cohorts 3 + 4)

Cohort^a	N	Genital warts		Rate difference (95% CI)	OR
Cohort^a	N	No	Yes	Rate difference (95% CI)
1	659	628 (95.3%)	31 (4.7%)	0.0302 (0.0109, 0.052)P = 0.0018	2.8877 (1.426; 6.226) p = 0.0016
3	714	702(98.3%)	12(1.7%)	0.0302 (0.0109, 0.052)P = 0.0018	2.8877 (1.426; 6.226) p = 0.0016
2	600	592(98.7%)	8(1.3%)	0.0106(−0.0042, 0.0255)P = 0.1598	4.9595 (0.660; 220.656) p = 0.1649
4	368	367(99.7%)	1(0.3%)	0.0106(−0.0042, 0.0255)P = 0.1598	4.9595 (0.660; 220.656) p = 0.1649
1 + 2	1259	1220(96.9%)	39(3.1%)	0.019(0.0068, 0.032) P = 0.0022	2.6287 (1.364; 5.395) p = 0.0018
3 + 4	1082	1069(98.8%)	13(1.2%)	0.019(0.0068, 0.032) P = 0.0022	2.6287 (1.364; 5.395) p = 0.0018

^aCohort 1 born 1983/84 analyzed in 2009/10; cohort 2 born in 1988/89 analyzed in 2009/10; cohort 3 born 1988/89 analyzed in 2014/15; cohort 4 born 1993/94 analyzed in 2014/15