Table 3 Statistical calculation using T-test, Fisher’s exact test and GLM on all serotype 8 IPD from 1999 to 2019
From: Molecular characterization and epidemiology of Streptococcus pneumoniae serotype 8 in Denmark
Age | 1999–2007 | 2008–2010 | 2011–2019 | 2008–2010 versus 1999–2007 (before and after PCV7) | 2011–2019 versus 2008–2010 (before and after PCV13) | 2011–2019 versus 1999–2007 (before PCV7 and after PCV13) | 1999–2019 | 2011–2019 |
|---|---|---|---|---|---|---|---|---|
Mean serotype 8 IPD incidence per 100,000. 95% confidence interval of the mean incidence (lower CI; upper CI) | Two tailed Fisher’s exact test: IRR, 95% confidence interval (lower CI; upper CI). | GLM: IRR, 95% confidence interval (lower CI; upper CI). | ||||||
< 2 | 0.51 (0.10–0.92) | 0.52 (−0.6–1.64) | 1.20 (0.48–1.91) | 1.02 (0.21–5.03) P = 1 | 2.33 (0.53–10.32) P = 0.38 | 2.37 (0.90–6.23) P = 0.11 | 1.07 (0.92–1.17) P = 0.09 | 1.08 (0.86–1.39) P = 0.49 |
2–4 | 0 (NA-NA) | 0 (NA-NA) | 0 (NA-NA) | NA P = 1 | NA P = 1 | NA P = 1 | NA | NA |
5–14 | 0.11 (−0.03–0.26) | 0 (NA-NA) | 0.12 (0.02–0.21) | 0 (0-NA) P = 0.20 | inf (NA-inf) P = 0.20 | 1.02 (0.36–2.92) P = 1 | 1.00 (0.78–1.28) P = 0.99 | 1.00 (0.42–2.40) P = 0.99 |
15–44 | 0.37 (0.30–0.43) | 0.33 (0.13–0.53) | 0.69 (0.42–0.95) | 0.89 (0.55–1.45) P = 0.72 | 2.11 (1.33–3.35) P < 0.001 | 1.89 (1.42–2.52) P < 0.001 | 1.07 (0.96–1.92) P = 0.23 | 1.17 (0.86–1.67) P = 0.33 |
45–64 | 1.26 (1.06–1.46) | 1.39 (0.90–1.88) | 2.71 (2.04–3.37) | 1.10 (0.82–1.47) P = 0.54 | 1.95 (1.49–2.55) P < 0.001 | 2.14 (1.78–2.58) P < 0.001 | 1.06 (1.01–1.12) P = 0.03 | 1.09 (0.93–1.28) P = 0.28 |
65–74 | 2.98 (2.46–3.49) | 2.70 (1.22–4.17) | 6.41 (4.27–8.56) | 0.92 (0.64–1.30) P = 0.66 | 2.40 (1.74–3.30) P < 0.001 | 2.20 (1.78–2.71) P < 0.001 | 1.04 (1.01–1.08) P = 0.02 | 1.13 (1.02–1.26) P = 0.02 |
75–84 | 3.59 (2.74–4.44) | 5.16 (1.53–8.80) | 7.62 (5.88–9.36) | 1.44 (1.00–2.07) P = 0.06 | 1.49 (1.08–2.07) P = 0.02 | 2.15 (1.68–2.74) P < 0.001 | 1.04 (1.01–1.08) P = 0.01 | 1.02 (0.93–1.11) P = 0.73 |
85+ | 3.07 (2.29–3.86) | 6.10 (−3.47–15.6) | 11.34 (7.42–15.26) | 1.97 (1.11–3.50) P = 0.022 | 1.89 (1.18–3.03) P = 0.0073 | 3.72 (2.47–5.61) P < 0.001 | 1.1 (1.07–1.13) P < 0.001 | 1.14 (1.06–1.23) P < 0.001 |
Total | 0.99 (0.89–1.09) | 1.14 (0.91–1.38) | 2.40 (1.73–3.07) | 1.15 (0.97–1.36) P = 0.10 | 2.11 (1.81–2.46) P < 0.001 | 2.43 (2.18–2.70) P < 0.001 | 1.08 (1.02–1.14) P = 0.015 | 1.12 (0.95–1.33) P = 0.20 |