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Table 5 Result of bivariate and multivariate analysis of factors associated with attrition

From: A 17 year experience of attrition from care among HIV infected children in Nnewi South-East Nigeria

Variable Total PT Years Attrition
(%)
P-value Estimated timeto event (years) p-value Attrition/1000PY B HR P-value
Total 1114 5109.7 550(49.4)   7.3   108    
Clinical stage           < 0.001c
 WHO stage 1 122 646.1 47(38.5)   11.5 < 0.001 73 −1.81 0.16(0.11–0.25) < 0.001
 WHO stage 2 275 1488.2 114(41.5) < 0.001a 11.0   77 −1.62 0.20(0.14–0.28) < 0.001
 WHO stage 3 597 2767.0 300(50.3)   6.7   108 −0.96 0.39(0.29–0.52) < 0.001
 WHO stage 4 107 203.8 76(71.0)   0.4   373 Reference
Use of ARVs
 Yes 866 4762.9 328(37.9) < 0.001a 13.1 < 0.001b 69 −2.13 0.12(0.09–0.15) < 0.001c
 No 248 346.8 222(89.5)   0.5   640 Reference  
Sex           0.873
 Male 547 2603.9 266(48.6) 0.626 7.4 0.375 102 5.09 161.99 0.859
 Female 567 2505.8 284(50.1)   6.7   113 5.04 154.27 0.860
Enrolment Age (years)           0.001c
  < 1 183 874.8 104(56.8)   5.3   568 0.72 2.05 (1.40–3.00) < 0.001c
 1 to < 5 423 2205.2 225(53.2) 0.001a 6.9 0.121 102 0.35 1.41 (1.02–1.96) 0.037
 5- < 10 307 1371.9 144(46.9)   6.8   105 0.16 1.17(0.83–1.66) 0.362
 10 to < 15 201 657.8 77(38.3)   7.3   117 Reference
Caregiver           0.142
 Parent(s) 718 3721.1 307(42.8)   11.5   83 −0.21 0.81 (0.49–1.34) 0.417
 Sibling 13 46.8 1(7.7)    21 −1.65 0.19(0.03–1.45) 0.109
 Extended family member 201 910.6 95(47.3) 0.026a 7.8 0.073 104 −0.01 0.99(0.59–1.68) 0.981
 Others 32 138.5 17(53.1)   5.1   123 Reference
Place of residence           0.577
 Same state ≤15 km radius 162 810.9 79(48.8) 0.058 8.1 0.065 97 −0.21 0.81(0.49–1.34) 0.299
 Same state > 15 km from site 820 3839.7 400(48.8)   7.5   104 −0.11 0.90(0.65–1.24) 0.515
 Other states 132 459.1 71(53.8)   3.9   155 Reference
Period of enrolment           < 0.001c
 2003–2005 142 889.2 70(49.3)   9.2   79 −0.25 0.78(0.38–1.63) 0.512
 2006–2008 394 2300.7 194(49.2)   8.3 0.001b 84 −0.67 0.51(0.25–1.04) 0.063
 2009–2011 317 1171.7 186(58.7) < 0.001a 5.5   159 −0.19 0.83(0.41–1.67) 0.595
 2012–2014 137 499.8 58(42.3)   5.2   116 −0.05 0.95(0.46–1.97) 0.897
 2015–2017 76 191.4 29(38.2)   3.5   152 −0.00 1.00(0.46–2.20) 0.997
 2018–2019 48 57.0 13(27.1)   2.0   228 Reference
  1. aStatistically significant chi-square test bStatistically significant Log rank (Kaplan Meier)
  2. cStatistically significant Cox regression B = regression coefficient HR = Hazard ratio