Fig. 1

Timeline of B.p aerosol challenge and sample collection from rhesus macaques. Infant rhesus macaques were infected with B.p by aerosol challenge on day 0 (empty arrow). A naive animal and a challenged animal were cohoused in one cage at 2 dpi for transmission of the infection (solid arrow). The circles indicate detection time points (empty for aerosol-challenged animals; solid for transmission animals). Coughing frequency was monitored every day