Characteristics | All patients | Patients with pneumonia | Patients without pneumonia | p-value* |
---|---|---|---|---|
(n = 107) | (n = 27) | (n = 80) | ||
n (%) | n (%) | n (%) | ||
Male gender | 63 (58.9%) | 18 (66.7%) | 45 (56.3%) | 0.342 |
Median age, y | 38 (20–83) | 51 (24–83) | 32.5 (20–72) | < 0.001 |
Age > 50 y | 32 (29.9%) | 14 (51.9%) | 18 (22.5%) | 0.004 |
Median BMI, kg/m2 | 23.1 (18.1–46.1) | 25.0 (19.2–43.8) | 22.8 (18.1–46.1) | 0.007 |
BMI ≥25 kg/m2 | 37 (34.6%) | 14 (51.9%) | 23 (28.8%) | 0.029 |
Risk factor for COVID-19 infection | ||||
Contact confirmed COVID-19 patients | 86 (80.6%) | 20 (74.1%) | 66 (82.5%) | 0.340 |
Imported patientsa | 15 (14.0%) | 4 (14.8%) | 11 (13.8%) | 0.890 |
Visiting public area | 6 (5.6%) | 3 (11.1%) | 3 (3.8%) | 0.151 |
Presence of comorbidities | 31 (29.0%) | 14 (51.9%) | 17 (21.3%) | 0.002 |
Diabetes mellitus | 12 (11.2%) | 7 (25.9%) | 5 (6.3%) | 0.005 |
Hypertension | 11 (10.3%) | 7 (25.9%) | 4 (5.0%) | 0.002 |
Dyslipidemia | 6 (5.6%) | 1 (3.7%) | 5 (6.3%) | 0.619 |
Liver disease | 4 (3.7%) | 0 (0.0%) | 4 (5.0%) | 0.183 |
Malignancy | 4 (3.7%), | 4 (14.8%) | 0 (0.0%) | < 0.001 |
Neurologic disease | 3 (2.8%) | 2 (7.4%) | 1 (1.3%) | 0.094 |
Heart disease | 2 (1.9%) | 1 (3.7%) | 1 (1.3%) | 0.416 |
Lung disease | 2 (1.9%) | 0 (0.0%) | 2 (2.5%) | 0.407 |
Kidney disease | 1 (0.9%) | 0 (0.0%) | 1 (1.3%) | 0.559 |
Presenting symptoms | ||||
Fever/history of fever | 83 (77.6%) | 26 (96.3%) | 57 (71.3%) | 0.007 |
Median BT, °C | 37.2 (35.7–39.5) | 37.5 (36.6–38.9) | 37.2 (35.7–39.5) | 0.053 |
BT ≥37.5 °C | 48 (44.8%) | 18 (66.7%) | 30 (37.5%) | 0.008 |
Cough | 64 (58.9%) | 20 (74.1%) | 44 (55.0%) | 0.080 |
Sore throat | 39 (36.4%) | 9 (33.3%) | 30 (37.5%) | 0.697 |
Myalgia | 28 (26.2%) | 5 (18.5%) | 23 (28.8%) | 0.296 |
Rhinorrhea | 24 (22.4%) | 4 (14.8%) | 20 (25.0%) | 0.273 |
Dyspnea | 23 (21.5%) | 15 (55.6%) | 8 (10.0%) | < 0.001 |
Headache | 16 (15.0%) | 2 (7.4%) | 14 (17.5%) | 0.204 |
Productive sputum | 12 (11.2%) | 4 (14.8%) | 8 (10.0%) | 0.493 |
Diarrhea | 10 (9.3%) | 4 (14.8%) | 6 (7.5%) | 0.259 |
Desaturationb | 6 (5.6%) | 6 (22.2%) | 0 (0.0%) | < 0.001 |
Clinical features at the time of admission | ||||
URI | 61 (57.0%) | 3 (11.1%) | 58 (72.5%) | < 0.001 |
Pneumonia | 19 (17.8%) | 19 (70.4%) | 0 (0.0%) | < 0.001 |
Acute febrile illness | 18 (16.8%) | 2 (7.4%) | 16 (20.0%) | 0.130 |
Bronchitis | 2 (1.9%) | 2 (7.4%) | 0 (0.0%) | 0.014 |
Acute diarrhea | 1 (0.9%) | 0 (0.0%) | 1 (1.3%) | 0.559 |
Asymptomatic infection | 6 (5.6%) | 1 (3.7%) | 5 (6.3%) | 0.619 |
Incubation period, d | 5 (1–19) | 6.5 (1–15) | 4 (1–19) | 0.307 |
Time from symptom onset to admission, d | 4 (0–18) | 5 (1–18) | 4 (0–15) | 0.166 |
Scoring of severity on the day of admission | ||||
NEWS2 score ≥ 5 | 10 (9.3%) | 9 (33.3%) | 1 (1.3%) | < 0.001 |
CRB-65 score ≥ 2 | 5 (4.7%) | 5 (18.5%) | 0 (0.0%) | < 0.001 |
qSOFA score ≥ 2 | 8 (7.5%) | 7 (25.9%) | 1 (1.3%) | < 0.001 |
Baseline laboratory findings | ||||
Hemoglobin, g/dL | 13.9 (9.5–17.4) | 14.0 (9.9–17.4) | 13.7 (9.5–17.4) | 0.581 |
WBC count, /mm3 | 5070 | 5190 | 5035 | 0.331 |
(2040-13,180) | (3380-13,180) | (2040-11,310) | ||
Lymphocyte count, /mm3 | 1559 (80–3231) | 1108 (80–2569) | 1752 (490–3231) | < 0.001 |
< 1000/mm3 | 14 (13.1%) | 11 (40.7%) | 3 (3.8%) | < 0.001 |
Atypical lymphocytosis | 17 (15.9%) | 8 (29.6%) | 9 (11.3%) | 0.024 |
Platelet count, /mm3 | 217,000 | 191,000 | 221,000 | 0.166 |
(104,000-562,000) | (137,000-562,000) | (104,000-555,000) | ||
C-reactive protein, mg/L | 6.2 (0.6–350.0) | 35.9 (0.6–350.0) | 2.8 (0.6–41.8) | < 0.001 |
CRP > 10 mg/L | 49 (45.8%) | 24 (88.9%) | 13 (16.3%) | < 0.001 |
Total bilirubin, mg/dL | 0.6 (0.1–2.3) | 0.6 (0.1–1.3) | 0.5 (0.1–2.3) | 0.211 |
Direct bilirubin, mg/dL | 0.2 (0.1–0.8) | 0.3 (0.1–0.7) | 0.2 (0.1–0.8) | 0.076 |
AST, U/L | 23 (9–284) | 31 (16–79) | 21 (9–284) | 0.002 |
ALT, U/L | 24 (7–162) | 26 (10–140) | 24 (7–162) | 0.277 |
Alkaline phosphatase, U/L | 64 (27–121) | 66 (32–121) | 64 (27–102) | 0.287 |
Albumin, g/dL | 4.3 (2.6–5.0) | 4.0 (2.6–5.0) | 4.3 (3.6–5.0) | < 0.001 |
Globulin, g/dL | 3.2 (2.3–4.5) | 3.6 (2.7–4.5) | 3.1 (2.3–4.3) | < 0.001 |
Blood urea nitrogen, mg/dL | 11.6 (4.0–40.3) | 12.2 (4.0–40.3) | 11.5 (5.4–29.2) | 0.427 |
Creatinine, mg/dL | 0.8 (0.4–2.5) | 0.8 (0.4–1.6) | 0.8 (0.5–2.5) | 0.250 |