Table 1 Drug resistance conferring-mutations and their correlation with phenotypic drug resistance
Antibiotic | Gene | Amino acid change | Phenotypicresistence | Genome coverage | Mutation frequency | Isolate |
|---|---|---|---|---|---|---|
INH | katG | S315T | yes | 95x | 1 | TB1–8 |
RIF | rpoB | D435V | yes | 102x | 1 | TB1–8 |
STR | Rrs | C517T | yes | 147x | 1 | TB1–8 |
OFX- LVX- MXF | gyrA | D94H | yes | 71x | 1 | TB3–5, TB7–8 |
OFX- LVX | gyrA | A90V | yes | 77x | 0.85 | TB6 |
PZA | pncA | T177fs | yes | 47x | 1 | TB7–8 |
ETH | ethA | T88fs | no | 53x | 0.6 | TB7–8 |
AMGs | 5’utr-whiB7 | 3568733A > C | no | 73x | 1 | TB7–8 |
CFZ- BDQ | Rv0678 | D47fs | yes (CFZ) | 45x | 0.5 | TB7–8 |