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Table 2 Univariate logistic regression of progression factors in patients with COVID-19

From: Development and validation of a simple-to-use nomogram to predict the deterioration and survival of patients with COVID-19

Variables OR 95CI% Estimate S. E z value P value
Age (years) 1.339 1.191–1.498 0.041 0.012 3.399 0.001b
Sex
 Male 1
 Female 0.699 0.337–1.448 −0.358 0.372 −0.964 0.335
 Smoking 1.598 0.668–3.823 0.469 0.445 1.054 0.292
 Hypertension 3.96 1.864–8.415 1.376 0.385 3.579 3.452E-04b
 Diabetes mellitus 5.586 2.324–13.426 1.720 0.447 3.845 1.207E-04b
 Coronary heart disease 8.542 2.678–27.24 2.145 0.592 3.625 2.889E-04b
 Cerebrovascular diseases 5.29 1.347–20.777 1.646 0.698 2.358 0.018b
 COPD 2.497 0.465–13.404 0.915 0.857 1.067 0.286
 Cancer 8.625 2.193–33.922 2.155 0.699 3.084 0.002b
 Immunodeficiency 1.00E+ 10 0 16.392 882.743 0.019 0.985
 White blood cells 1.339 1.197–1.498 0.292 0.057 5.116 3.120E-07b
 Neutrophil 1.225 1.12–1.34 0.203 0.046 4.423 9.740E-06b
 Monocyte 0 0–0.027 −7.771 2.122 −3.662 2.507E-04b
Lymphocyte
  < 0.8(×109/L) 1  
  ≥ 0.8(×109/L) 0.012 0.002–0.087 −4.449 1.026 −4.337 1.440E-05b
 Hemoglobin (g/L) 0.942 0.92–0.965 −0.060 0.012 −4.969 6.740E-07b
 Platelet (×109/L) 0.984 0.976–0.993 −0.016 0.004 −3.627 2.868E-04b
 PT (s) 1.785 1.335–2.387 0.580 0.148 3.912 9.140E-05b
 APTT (s) 1.05 0.994–1.108 0.049 0.028 1.747 0.081
 Fibrinogen (g/L) 0.542 0.363–0.81 −0.612 0.205 −2.990 0.003b
 D-Dimer (mg/L) 1.114 1.059–1.171 0.108 0.026 4.201 2.650E-05b
 TBIL (μmol/L) 1.018 0.963–1.075 0.017 0.028 0.624 0.533
 DBIL (μmol/L) 1.023 0.983–1.065 0.023 0.021 1.129 0.259
 Albumin (g/L) 0.876 0.819–0.938 −0.132 0.035 −3.814 1.369E-04b
 Globulin (g/L) 1.016 0.932–1.108 0.016 0.044 0.362 0.717
 ALT (U/L) 1.011 0.997–1.025 0.011 0.007 1.553 0.120b
 AST (U/L) 1.032 1.011–1.054 0.032 0.011 2.954 0.003b
 ALT peak (U/L) 1.005 1.001–1.009 0.005 0.002 2.400 0.016b
 AST peak (U/L) 1.007 1–1.013 0.007 0.003 1.968 0.049b
 Creatinine (μmol/L) 1.007 1–1.013 0.007 0.003 2.057 0.040b
 Creatinine peak (μmol/L) 1.01 1.003–1.016 0.010 0.003 2.953 0.003b
 CK (U/L) 1.001 1–1.003 0.001 0.001 1.445 0.148
 CKMB (U/L) 1.005 0.999–1.012 0.005 0.003 1.621 0.105
LDH (U/L)
  < 400 U/L 1
  ≥ 400 U/L 17.472 7.053–43.284 2.861 0.463 6.180 6.390E-10b
 CRP (mg/L) 1.029 1.02–1.039 0.029 0.004 6.468 9.960E-11b
 PCT (ng/L) 1.107 1.031–1.189 0.102 0.036 2.793 0.005b
  1. Notes: OR odds ratio, CI confidence interval, S. E standard error, COPD chronic obstructive pulmonary disease, PT prothrombin time, APTT activated partial thromboplastin time, TBIL total bilirubin, DBIL direct bilirubin, ALT alanine aminotransferase, AST aspartate Aminotransferase, LDH lactate dehydrogenase, CK creatine kinase, CKMB Creatine kinase-MB, CRP C-reactive protein, PCT procalcitonin, NA not available; bP < 0.05