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Table 4 Subgroup analysis of IL-6 in the diagnosis of sepsis

From: Diagnostic value of neutrophil CD64, procalcitonin, and interleukin-6 in sepsis: a meta-analysis

category studies SEN (95% CI) SPE (95%CI) DOR (95% CI) AUC (95% CI) SEN-I2 (%) SPE-I2 (%)
overall 16 0.72[0.65, 0.78] 0.70[0.62,0.76] 6[4, 9] 0.77[0.73,0.80] 89.27 85.07
subgroup analysis based on sample size
 size≥100 10 0.66[0.58,0.3] 0.73[0.64,0.80] 5[3,8] 0.75[0.71,0.78] 92.34 88.99
 size< 100 6 0.83[0.73,0.83] 0.64[0.51,0.75] 8[5,14] 0.81[0.77,0.84] 52.42 62.91
subgroup analysis based on country
 China 4
non-China 12 0.69[0.59, 0.77] 0.70[0.63,0.77] 5[3, 8] 0.75[0.71, 0.79] 80.86 74.47
subgroup analysis based on patient scource
 ICU 10 0.71[0.60, 0.80] 0.74[0.66,0.81] 8[4, 14] 0.80[0.76, 0.83] 91.94 80.76
non-ICU 6 0.73[0.64, 0.80] 0.66[0.54,0.75] 5[3, 8] 0.74[0.70, 0.78] 84.28 84.97
subgroup analysis based on assay method
 EIA 8 0.75[0.64, 0.83] 0.70[0.63,0.76] 7[4, 12] 0.77[0.73, 0.81] 91.31 67.89
 ECLI 8 0.69[0.59, 0.77] 0.69[0.56,0.80] 5[3, 9] 0.75[0.71, 0.78] 83.28 90.73
subgroup analysis based on mean age
 age ≥ 65 y 1
 age < 65 y 9 0.71[0.61, 0.79] 0.74[0.63, 0.82] 7[4, 13] 0.78 [0.75,0.82] 90.46 90.59