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Table 4 Subgroup analysis of IL-6 in the diagnosis of sepsis

From: Diagnostic value of neutrophil CD64, procalcitonin, and interleukin-6 in sepsis: a meta-analysis

category

studies

SEN (95% CI)

SPE (95%CI)

DOR (95% CI)

AUC (95% CI)

SEN-I2 (%)

SPE-I2 (%)

overall

16

0.72[0.65, 0.78]

0.70[0.62,0.76]

6[4, 9]

0.77[0.73,0.80]

89.27

85.07

subgroup analysis based on sample size

 size≥100

10

0.66[0.58,0.3]

0.73[0.64,0.80]

5[3,8]

0.75[0.71,0.78]

92.34

88.99

 size< 100

6

0.83[0.73,0.83]

0.64[0.51,0.75]

8[5,14]

0.81[0.77,0.84]

52.42

62.91

subgroup analysis based on country

 China

4

–

–

–

–

–

–

non-China

12

0.69[0.59, 0.77]

0.70[0.63,0.77]

5[3, 8]

0.75[0.71, 0.79]

80.86

74.47

subgroup analysis based on patient scource

 ICU

10

0.71[0.60, 0.80]

0.74[0.66,0.81]

8[4, 14]

0.80[0.76, 0.83]

91.94

80.76

non-ICU

6

0.73[0.64, 0.80]

0.66[0.54,0.75]

5[3, 8]

0.74[0.70, 0.78]

84.28

84.97

subgroup analysis based on assay method

 EIA

8

0.75[0.64, 0.83]

0.70[0.63,0.76]

7[4, 12]

0.77[0.73, 0.81]

91.31

67.89

 ECLI

8

0.69[0.59, 0.77]

0.69[0.56,0.80]

5[3, 9]

0.75[0.71, 0.78]

83.28

90.73

subgroup analysis based on mean age

 age ≥ 65 y

1

–

–

–

–

–

–

 age < 65 y

9

0.71[0.61, 0.79]

0.74[0.63, 0.82]

7[4, 13]

0.78 [0.75,0.82]

90.46

90.59