From: Diagnostic value of neutrophil CD64, procalcitonin, and interleukin-6 in sepsis: a meta-analysis
category | studies | SEN (95% CI) | SPE (95%CI) | DOR (95% CI) | AUC (95% CI) | SEN-I2 (%) | SPE-I2 (%) |
---|---|---|---|---|---|---|---|
overall | 16 | 0.72[0.65, 0.78] | 0.70[0.62,0.76] | 6[4, 9] | 0.77[0.73,0.80] | 89.27 | 85.07 |
subgroup analysis based on sample size | |||||||
 size≥100 | 10 | 0.66[0.58,0.3] | 0.73[0.64,0.80] | 5[3,8] | 0.75[0.71,0.78] | 92.34 | 88.99 |
 size< 100 | 6 | 0.83[0.73,0.83] | 0.64[0.51,0.75] | 8[5,14] | 0.81[0.77,0.84] | 52.42 | 62.91 |
subgroup analysis based on country | |||||||
 China | 4 | – | – | – | – | – | – |
non-China | 12 | 0.69[0.59, 0.77] | 0.70[0.63,0.77] | 5[3, 8] | 0.75[0.71, 0.79] | 80.86 | 74.47 |
subgroup analysis based on patient scource | |||||||
 ICU | 10 | 0.71[0.60, 0.80] | 0.74[0.66,0.81] | 8[4, 14] | 0.80[0.76, 0.83] | 91.94 | 80.76 |
non-ICU | 6 | 0.73[0.64, 0.80] | 0.66[0.54,0.75] | 5[3, 8] | 0.74[0.70, 0.78] | 84.28 | 84.97 |
subgroup analysis based on assay method | |||||||
 EIA | 8 | 0.75[0.64, 0.83] | 0.70[0.63,0.76] | 7[4, 12] | 0.77[0.73, 0.81] | 91.31 | 67.89 |
 ECLI | 8 | 0.69[0.59, 0.77] | 0.69[0.56,0.80] | 5[3, 9] | 0.75[0.71, 0.78] | 83.28 | 90.73 |
subgroup analysis based on mean age | |||||||
 age ≥ 65 y | 1 | – | – | – | – | – | – |
 age < 65 y | 9 | 0.71[0.61, 0.79] | 0.74[0.63, 0.82] | 7[4, 13] | 0.78 [0.75,0.82] | 90.46 | 90.59 |