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Table 3 Subgroup analysis of PCT in the diagnosis of sepsis

From: Diagnostic value of neutrophil CD64, procalcitonin, and interleukin-6 in sepsis: a meta-analysis

category studies SEN (95% CI) SPE (95%CI) DOR (95% CI) AUC (95% CI) SEN-I2 (%) SPE-I2 (%)
overall 43 0.82[0.78, 0.85] 0.78[0.74,0.82] 16[11, 23] 0.87[0.83,0.89] 87.23 83.99
subgroup analysis based on sample size
 size≥100 27 0.82[0.77,0.86] 0.78[0.73,0.83] 16[11,25] 0.87[0.84,0.90] 90.42 88.98
 size< 100 16 0.81[0.74,0.86] 0.78[0.71,0.83] 15[9.25] 0.86[0.83,0.89] 74.74 52.18
subgroup analysis based on country
 China 11 0.79[0.74, 0.84] 0.79[0.73,0.85] 15[8, 26] 0.86[0.83, 0.89] 78.26 83.92
 non-China 33 0.83[0.77, 0.87] 0.77[0.72,0.82] 16[11, 25] 0.87[0.84, 0.89] 89.29 84.48
subgroup analysis based on patient scource
 ICU 27 0.82[0.77, 0.86] 0.78[0.72,0.82] 16[10, 24] 0.86[0.83, 0.89] 86.20 76.10
 non-ICU 10 0.77[0.72, 0.82] 0.74[0.64,0.81] 9[6, 15] 0.82[0.78, 0.85] 74.39 90.16
subgroup analysis based on mean age
 age ≥ 65 y 8 0.79[0.72, 0.8] 0.84[0.75,0.90] 20[12, 34] 0.88[0.85, 0.91] 86.45 74.39
 age < 65 y 20 0.80[0.73, 0.86] 0.81[0.76,0.85] 17[10, 29] 0.87[0.84, 0.90] 84.01 73.73