Diagnostic value of neutrophil CD64, procalcitonin, and interleukin-6 in sepsis: a meta-analysis

Table 3 Subgroup analysis of PCT in the diagnosis of sepsis

category	studies	SEN (95% CI)	SPE (95%CI)	DOR (95% CI)	AUC (95% CI)	SEN-I² (%)	SPE-I² (%)
overall	43	0.82[0.78, 0.85]	0.78[0.74,0.82]	16[11, 23]	0.87[0.83,0.89]	87.23	83.99
subgroup analysis based on sample size
size≥100	27	0.82[0.77,0.86]	0.78[0.73,0.83]	16[11,25]	0.87[0.84,0.90]	90.42	88.98
size< 100	16	0.81[0.74,0.86]	0.78[0.71,0.83]	15[9.25]	0.86[0.83,0.89]	74.74	52.18
subgroup analysis based on country
China	11	0.79[0.74, 0.84]	0.79[0.73,0.85]	15[8, 26]	0.86[0.83, 0.89]	78.26	83.92
non-China	33	0.83[0.77, 0.87]	0.77[0.72,0.82]	16[11, 25]	0.87[0.84, 0.89]	89.29	84.48
subgroup analysis based on patient scource
ICU	27	0.82[0.77, 0.86]	0.78[0.72,0.82]	16[10, 24]	0.86[0.83, 0.89]	86.20	76.10
non-ICU	10	0.77[0.72, 0.82]	0.74[0.64,0.81]	9[6, 15]	0.82[0.78, 0.85]	74.39	90.16
subgroup analysis based on mean age
age ≥ 65 y	8	0.79[0.72, 0.8]	0.84[0.75,0.90]	20[12, 34]	0.88[0.85, 0.91]	86.45	74.39
age < 65 y	20	0.80[0.73, 0.86]	0.81[0.76,0.85]	17[10, 29]	0.87[0.84, 0.90]	84.01	73.73