From: Diagnostic value of neutrophil CD64, procalcitonin, and interleukin-6 in sepsis: a meta-analysis
category | studies | SEN (95% CI) | SPE (95%CI) | DOR (95% CI) | AUC (95% CI) | SEN-I2 (%) | SPE-I2 (%) |
---|---|---|---|---|---|---|---|
overall | 19 | 0.89 [0.82, 0.93] | 0.88 [0.84,0.92] | 59 [30, 115] | 0.94 [0.91,0.96] | 90.39 | 76.03 |
subgroup analysis based on sample size | |||||||
 size≥100 | 8 | 0.82 [0.71,0.89] | 0.87 [0.81,0.91] | 29 [13,64] | 0.91 [0.88,0.93] | 91.53 | 78.72 |
 size< 100 | 11 | 0.92 [0.86,0.96] | 0.90 [0.84,0.94] | 105 [44,252] | 0.95 [0.93,0.97] | 62.09 | 13.49 |
subgroup analysis based on country | |||||||
 China | 6 | 0.89 [0.84, 0.93] | 0.86 [0.80,0.91] | 53 [30, 92] | 0.92 [0.89, 0.94] | 49.79 | 0.00 |
 non-China | 13 | 0.88 [0.79, 0.94] | 0.89 [0.84,0.93] | 64 [24, 168] | 0.94 [0.92, 0.96] | 92.42 | 83.07 |
subgroup analysis based on patient scource | |||||||
 ICU | 13 | 0.89 [0.80, 0.94] | 0.90 [0.86,0.93] | 73 [29, 183] | 0.94 [0.92, 0.96] | 93.18 | 78.96 |
 non-ICU | 4 | – | – | – | – | – | – |
subgroup analysis based on assay method | |||||||
 FMC | 16 | 0.87 [0.82, 0.91] | 0.88 [0.83,0.91] | 50 [27, 96] | 0.94 [0.91, 0.96] | 86.71 | 71.13 |
 Leuko64 kit | 3 | – | – | – | – | – | – |
subgroup analysis based on mean age | |||||||
 age ≥ 65 y | 2 | – | – | – | – | – | – |
 age < 65 y | 11 | 0.89 [0.81, 0.94] | 0.90 [0.86,0.93] | 77 [37, 164] | 0.94 [0.91, 0.96] | 90.02 | 61.12 |