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Table 2 Subgroup analysis of CD64 in the diagnosis of sepsis

From: Diagnostic value of neutrophil CD64, procalcitonin, and interleukin-6 in sepsis: a meta-analysis

category studies SEN (95% CI) SPE (95%CI) DOR (95% CI) AUC (95% CI) SEN-I2 (%) SPE-I2 (%)
overall 19 0.89 [0.82, 0.93] 0.88 [0.84,0.92] 59 [30, 115] 0.94 [0.91,0.96] 90.39 76.03
subgroup analysis based on sample size
 size≥100 8 0.82 [0.71,0.89] 0.87 [0.81,0.91] 29 [13,64] 0.91 [0.88,0.93] 91.53 78.72
 size< 100 11 0.92 [0.86,0.96] 0.90 [0.84,0.94] 105 [44,252] 0.95 [0.93,0.97] 62.09 13.49
subgroup analysis based on country
 China 6 0.89 [0.84, 0.93] 0.86 [0.80,0.91] 53 [30, 92] 0.92 [0.89, 0.94] 49.79 0.00
 non-China 13 0.88 [0.79, 0.94] 0.89 [0.84,0.93] 64 [24, 168] 0.94 [0.92, 0.96] 92.42 83.07
subgroup analysis based on patient scource
 ICU 13 0.89 [0.80, 0.94] 0.90 [0.86,0.93] 73 [29, 183] 0.94 [0.92, 0.96] 93.18 78.96
 non-ICU 4
subgroup analysis based on assay method
 FMC 16 0.87 [0.82, 0.91] 0.88 [0.83,0.91] 50 [27, 96] 0.94 [0.91, 0.96] 86.71 71.13
 Leuko64 kit 3
subgroup analysis based on mean age
 age ≥ 65 y 2
 age < 65 y 11 0.89 [0.81, 0.94] 0.90 [0.86,0.93] 77 [37, 164] 0.94 [0.91, 0.96] 90.02 61.12