Skip to main content

Table 1 The number of polar contacts observed between WT residue and neighbouring residues before and after the introduction of the RAM’s and Accessory Mutations

From: Interaction analysis of statistically enriched mutations identified in Cameroon recombinant subtype CRF02_AG that can influence the development of Dolutegravir drug resistance mutations

#

RAM’s

# Polar contacts

WT

Mutant

1

M50I

None

None

2

T66A

2 (His67, Ile73)

1 (Ile73)

3

L74M

1 (Glu87)

1 (Glu87)

4

L74I

1 (Glu87)

1 (Glu87)

5

G118S

None

None

6

S119R

3 (Thy29, Asn120, Thr122)

3 (Thy29, Glu92, Thr122)

7

P145S

1 (Gln148)

1 (Gln148)

8

Q148H

3 (Pro145, Ser147, Val151)

1 (Pro145)

9

R263K

2 (Thy17, Cys56)

1 (Cys56)

10

N155H

4 (Val151, Glu152, Leu158, Lys159)

5 (Ade21, Val151, Glu152, Leu158, Lys159)

#

Accessory Mutations

WT

Mutant

1

Q95K

2 (Ala98, Tyr99)

2 (Ala98, Tyr99)

2

T97A

4 (Thr93, Gly94, I101)

3 (Thr93, Gly94, Ile101)

3

G149A

4 (Gua18, Gln146, Glu152, Ser153)

4 (Gua18, Gln146, Glu152, Ser153)

4

E157Q

4 (Ser153, Met154, Lys156, Ile161)

5 (Thy20, Ade21, Ser153, Met154, Ile161)

5

D232N

3 (Asp229, Ile234, Lys236)

2 (Asp229, Ile234)

  1. The number in front of brackets is the total amount of interactions. Abbreviations used: Ade Adenine, Ala (A) Alanine, Asp (D) Aspartic acid, Glu (E) Glutamic acid, Gly (G) Glycine, Gua Guanine, His (H) Histidine, Ile (I) Isoleucine, Leu (L) Leucine, Lys (K) Lysine, Met (M) Methionine, Asn (N) Asparagine, Gln (Q) Glutamine, Arg (R) Arginine, RAM’s Resistance associated mutations, Ser (S) Serine, Thr (T) Threonine, Thy Thymidine, Tyr (Y) Tyrosine, WT Wild type. Bold indicates a change in amino acid and nucleotide. Three letter codes for IN protein residues and terminal end viral DNA nucleotides after 3′ processing are given