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Fig. 3 | BMC Infectious Diseases

Fig. 3

From: Interaction analysis of statistically enriched mutations identified in Cameroon recombinant subtype CRF02_AG that can influence the development of Dolutegravir drug resistance mutations

Fig. 3

3D tetrameric structure for HIV-1 CRF02_AG IN. a Three-dimensional tetrameric structure predicted for HIV-1 CRF_02 AG IN in complex with magnesium ions. Chain A: green, Chain B: cyan, Chain C: Magenta, Chain D: yellow, Magnesium ions shown as spheres coloured in green and Dolutegravir shown as sticks coloured in red. No DNA shown. b Structural superimposition of HIV-1 AG IN onto HIV-1 B (5U1C) in complex with MG ions. CRF02_AG IN: green, 5U1C: blue, MG ions shown as magenta spheres. c Locations of stabilizing and destabilizing mutations on HIV-1 integrase CRF02_AG structure. Mutations that affect the protein structure are labelled and shown as red sticks and mutations with no effects are also labelled and shown as blue sticks. Magnesium ions shown as spheres coloured in green and Dolutegravir shown as sticks coloured by atom type

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BMC Infectious Diseases

ISSN: 1471-2334

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