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Table 4 Analysis of factors affecting mortality using both the univariate and multivariable Cox proportional hazards model

From: The characteristics of laboratory tests at admission and the risk factors for adverse clinical outcomes of severe and critical COVID-19 patients

 

Univariate Model

Multivariable Model

Hazards ratio (95% CI)

p value

Hazards ratio (95% CI)

p value

Gender (male)

1.724 (1.103–2.694)

0.017

0.885 (0.533–1.470)

0.637

Age#

1.072 (1.055–1.089)

<0.001

1.066 (1.043–1.089)

< 0.001

> 60 years*

8.371 (4.701–14.910)

<0.001

-

-

Diabetes

2.187 (1.361–3.515)

0.001

1.148 (0.676–1.952)

0.609

Hypertension

2.012 (1.270–3.189)

0.003

0.852 (0.508–1.428)

0.543

Coronary heart disease

4.195 (2.198–8.008)

<0.001

1.081 (0.518–2.254)

0.836

White blood cell count #

1.187 (1.138–1.238)

<0.001

1.135 (1.080–1.192)

< 0.001

>10 × 109 per L &

3.993 (2.469–6.459)

<0.001

-

-

Ln (Glucose)#

3.561 (2.221–5.708)

<0.001

1.844 (0.931–3.649)

0.079

Ln (AST)#

3.452 (2.448–4.867)

<0.001

1.480 (0.983–2.229)

0.060

High C-reactive protein(>10 mg/L)

18.960 (4.658–77.170)

<0.001

3.907 (0.900–16.970)

0.069

High Creatinine (>104 μmol/L)

3.430 (1.981–5.938)

<0.001

1.209 (0.637–2.294)

0.562

Low Lymphocytes (<1 × 109 per L)

3.776 (2.150–6.635)

<0.001

1.516 (0.820–2.803)

0.185

  1. p < 0 .05 was considered statistically significant
  2. # Per unit increase of the variable; * Reference group is patients age ≤ 60 years; & Reference group is patients white blood cell count ≤10 × 109per L.