Table 4 - Baseline factors associated with Child-Pugh class worsening following viral eradication. Univariate and multivariate analysis
Baseline factors | Crude HR | 95% CI | Adjusted HR | 95% CI |
|---|---|---|---|---|
HIV infection | 0.68 | 0.21–2.15 | 0.51 | 0.15–1.73 |
Age (increasing years) | 1.00 | 0.98–1.02 | 1.00 | 0.98–1.02 |
Sex (ref. female) | 1.77 | 1.12–2.81 | 2.00 | 1.18–3.36 |
BMI: overweight/obese (ref. under-normalweight) | 0.88 | 0.58–1.34 | 0.79 | 0.51–1.22 |
Current/past alcohol use (ref. never) | 0.99 | 0.63–1.55 | 0.76 | 0.47–1.24 |
ALT (increasing IU/L) | 1.00 | 0.99–1.00 | 1.00 | 0.99–1.01 |
AST (increasing IU/L) | 1.00 | 0.99–1.00 | 0.99 | 0.98–1.00 |
Platelets (ref. > 100,000/μL) | 2.01 | 1.31–3.08 | 1.75 | 1.08–2.85 |
Albumin (decreasing g/dL) | 1.57 | 0.99–2.43 | 1.35 | 0.82–2.23 |
Bilirubin (increasing mg/dL) | 0.98 | 0.87–1.12 | 0.84 | 0.60–1.18 |
INR (increasing unit) | 2.15 | 1.45–3.19 | 2.41 | 1.51–3.84 |
HCV-genotype (3 vs others) | 1.51 | 0.80–2.84 | 1.54 | 0.75–3.17 |
Diabetes | 1.14 | 0.69–1.89 | 0.93 | 0.55–1.57 |
Anti-HBc+ | 1.02 | 0.63–1.65 | 1.05 | 0.63–1.76 |
Previous Interferon treatment | 0.82 | 0.52–1.29 | 0.77 | 0.48–1.23 |
Esophageal varices | 1.85 | 1.20–2.85 | 1.47 | 0.89–2.42 |
HCC | 2.32 | 1.20–4.49 | 1.88 | 0.87–4.08 |
Previous decompensating event | 1.97 | 1.17–3.31 | 1.12 | 0.60–2.11 |