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Table 4 - Baseline factors associated with Child-Pugh class worsening following viral eradication. Univariate and multivariate analysis

From: Liver function following hepatitis C virus eradication by direct acting antivirals in patients with liver cirrhosis: data from the PITER cohort

Baseline factors Crude HR 95% CI Adjusted HR 95% CI
HIV infection 0.68 0.21–2.15 0.51 0.15–1.73
Age (increasing years) 1.00 0.98–1.02 1.00 0.98–1.02
Sex (ref. female) 1.77 1.12–2.81 2.00 1.18–3.36
BMI: overweight/obese (ref. under-normalweight) 0.88 0.58–1.34 0.79 0.51–1.22
Current/past alcohol use (ref. never) 0.99 0.63–1.55 0.76 0.47–1.24
ALT (increasing IU/L) 1.00 0.99–1.00 1.00 0.99–1.01
AST (increasing IU/L) 1.00 0.99–1.00 0.99 0.98–1.00
Platelets (ref. > 100,000/μL) 2.01 1.31–3.08 1.75 1.08–2.85
Albumin (decreasing g/dL) 1.57 0.99–2.43 1.35 0.82–2.23
Bilirubin (increasing mg/dL) 0.98 0.87–1.12 0.84 0.60–1.18
INR (increasing unit) 2.15 1.45–3.19 2.41 1.51–3.84
HCV-genotype (3 vs others) 1.51 0.80–2.84 1.54 0.75–3.17
Diabetes 1.14 0.69–1.89 0.93 0.55–1.57
Anti-HBc+ 1.02 0.63–1.65 1.05 0.63–1.76
Previous Interferon treatment 0.82 0.52–1.29 0.77 0.48–1.23
Esophageal varices 1.85 1.20–2.85 1.47 0.89–2.42
HCC 2.32 1.20–4.49 1.88 0.87–4.08
Previous decompensating event 1.97 1.17–3.31 1.12 0.60–2.11