Table 1 - Baseline characteristics of cirrhotic patients
|  | HCV/HIV co-infected (N = 108*) | HCV mono-infected (N = 1242*) |  | |||
|---|---|---|---|---|---|---|
Quantitative variables | Median | IQR | Median | IQR | p** | |
Age (years) | 52.5 | 50–55 | 64.0 | 54–72 | < 0.001 | |
ALT (IU/L) | 63.0 | 40.0–91.0 | 74.0 | 47.0–115.0 | 0.01 | |
AST (IU/L) | 60.0 | 44.0–95.0 | 70.0 | 47.0–105.0 | 0.14 | |
Platelets/μL | 105,000 | 74,000–154,000 | 119,000 | 86,350–159,000 | 0.06 | |
Albumin (g/dL) | 3.9 | 3.5–4.2 | 3.9 | 3.6–4.2 | 0.48 | |
Bilirubin (mg/dL) | 0.8 | 0.6–1.3 | 0.9 | 0.6–1.1 | 0.54 | |
INR | 1.1 | 1.0–1.2 | 1.1 | 1.0–1.2 | 0.10 | |
Categorical variables | N. | % | N. | % | p*** | |
Sex | Male | 88 | 81.5 | 722 | 58.1 | < 0.001 |
Female | 20 | 18.5 | 520 | 41.9 | Â | |
BMI | Underweight | 5 | 4.6 | 14 | 1.1 | < 0.001 |
Normal | 70 | 64.8 | 514 | 41.4 | Â | |
Overweight | 25 | 23.2 | 550 | 44.3 | Â | |
Obese | 8 | 7.4 | 163 | 13.1 | Â | |
Alcohol use | Never | 50 | 52.1 | 803 | 66.0 | < 0.001 |
Current | 26 | 27.1 | 116 | 9.5 | Â | |
Past | 20 | 20.8 | 297 | 24.4 | Â | |
HCV- genotype | 1 (Non subtyped) | 5 | 4.6 | 36 | 2.9 | < 0.001 |
1a | 33 | 30.6 | 170 | 13.7 | Â | |
1b | 15 | 13.9 | 665 | 53.5 | Â | |
2 | 4 | 3.7 | 168 | 13.5 | Â | |
3 | 31 | 28.7 | 120 | 9.7 | Â | |
4 | 20 | 18.5 | 83 | 6.7 | Â | |
5 | 0 | 0.0 | 0 | 0.0 | Â | |
Diabetes | Yes | 16 | 14.8 | 259 | 20.9 | 0.14 |
No | 92 | 85.2 | 983 | 79.2 | Â | |
HBV Infection | Anti-HBc+/HBsAg+ | 4 | 3.7 | 15 | 1.2 | < 0.001 |
Anti-HBc+/HBsAg- | 47 | 43.5 | 262 | 21.1 | Â | |
No | 57 | 52.8 | 965 | 77.7 | Â | |
Previous Interferon | Yes | 30 | 27.8 | 415 | 33.4 | 0.23 |
No | 78 | 72.2 | 827 | 66.6 | Â | |
HCC | Yes | 1 | 0.9 | 78 | 6.3 | 0.02 |
No | 107 | 99.1 | 1164 | 93.7 | Â | |
Esophageal varices | Yes | 18 | 16.7 | 270 | 21.7 | 0.22 |
No | 90 | 83.3 | 972 | 78.3 | Â | |
Ascites | Yes | 10 | 9.3 | 81 | 6.5 | 0.28 |
No | 98 | 90.7 | 1161 | 93.5 | Â | |
Previous decompensation | Yes | 15 | 13.9 | 133 | 10.7 | 0.31 |
No | 93 | 86.1 | 1109 | 89.3 | Â | |
Child-Pugh Score | A-5 | 39 | 52.7 | 762 | 69.5 | < 0.001 |
A-6 | 14 | 18.9 | 242 | 22.1 | Â | |
B-7 | 12 | 16.2 | 58 | 5.3 | Â | |
B-8 | 8 | 10.8 | 28 | 2.6 | Â | |
B-9 | 0 | 0.0 | 6 | 0.6 | Â | |
C-10 | 1 | 1.4 | 0 | 0.0 | Â | |