Haematological abnormalities in children with sickle cell disease and non-severe malaria infection in western Kenya

Kosiyo, Paul; Otieno, Walter; Gitaka, Jesse; Munde, Elly O.; Ouma, Collins

doi:10.1186/s12879-021-06025-7

Table 3 Correlation of haematological parameters with Sickle cell genotype in children with and without P. falciparum infection

From: Haematological abnormalities in children with sickle cell disease and non-severe malaria infection in western Kenya

			Malaria negative (N = 132)				Malaria positive (N = 85)
Control Variable			MCV (fL)	MCH (Pg)	MCHC (gdL⁻)	RDW (%)	MCV (fL)	MCH (Pg)	MCHC (gdL⁻)	RDW (%)
Sickle cell anaemia (HbSS) (n = 11)							Sickle cell anaemia (HbSS) (n = 13)
Age and sex	RBC count	r	−0.362	−0.068	0.060	−0.634	−0.883	−0.750	−0.118	−0.725
	RBC count	P value	0.304	0.852	0.870	0.049	0.001	0.005	0.715	0.008
	Haematocrit	r	0.231	0.172	−0.086	− 0.918	− 0.555	− 0.418	0.273	− 0.718
	Haematocrit	P value	0.521	0.635	0.813	< 0.0001	0.061	0.176	0.391	0.009
	Haemoglobin	r	−0.218	0.032	0.563	−0.616	− 0.526	− 0.220	0.521	− 0.792
	Haemoglobin	P value	0.545	0.929	0.090	0.058	0.079	0.493	0.082	0.002
Sickle cell trait (HbAS) (n = 31)							Sickle cell trait (HbAS) (n = 14)
Age and sex	RBC count	r	−0.299	−0.494	−0.434	− 0.292	− 0.752	−0.797	− 0.305	−0.392
	RBC count	P value	0.116	0.006	0.019	0.125	0.003	0.001	0.311	0.185
	Haematocrit	r	0.515	0.221	−0.458	−0.507	−0.269	−0.369	− 0.394	−0.506
	Haematocrit	P value	0.004	0.249	0.013	0.005	0.375	0.214	0.183	0.078
	Haemoglobin	r	0.547	0.533	0.069	−0.694	−0.247	−0.235	−0.080	− 0.475
	Haemoglobin	P value	0.002	0.003	0.720	< 0.0001	0.417	0.441	0.796	0.101
Normal haemoglobin (HbAA) (n = 90)							Normal haemoglobin (HbAA) (n = 58)
Age and sex	RBC count	r	−0.324	−0.273	−0.401	− 0.235	− 0.393	−0.408	− 0.270	−0.399
	RBC count	P value	0.002	0.010	< 0.0001	0.027	0.003	0.002	0.043	0.002
	Haematocrit	r	0.524	0.143	−0.333	−0.361	0.139	.076	−0.072	−0.446
	Haematocrit	P value	< 0.0001	0.181	0.001	< 0.0001	0.302	0.573	0.593	0.001
	Haemoglobin	r	0.525	0.408	0.269	−0.664	0.257	0.317	0.285	−0.479
	Haemoglobin	P value	< 0.0001	< 0.0001	0.011	< 0.0001	0.053	0.016	0.032	0.001

Data are the partial correlations (r). Malaria negative patients (n = 132) and malaria positive patients (n = 85) with acute febrile illness were categorized on the basis of haemoglobin type. All statistical significance was determined by the partial correlation test (r) controlling for age and sex. Values in bold are statistically significant at P ≤ 0.05
Abbreviations: MCV Mean corpuscular volume, MCH mean corpuscular haemoglobin, MCHC mean corpuscular haemoglobin concentration, RBC-Red blood cells, RDW Red cell distribution width, r the measure of strength of Pearson’s correlation

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ISSN: 1471-2334

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