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Table 3 Correlation of haematological parameters with Sickle cell genotype in children with and without P. falciparum infection

From: Haematological abnormalities in children with sickle cell disease and non-severe malaria infection in western Kenya

  Malaria negative (N = 132) Malaria positive (N = 85)
Control Variable   MCV (fL) MCH (Pg) MCHC (gdL) RDW (%) MCV (fL) MCH (Pg) MCHC (gdL) RDW (%)
Sickle cell anaemia (HbSS) (n = 11) Sickle cell anaemia (HbSS) (n = 13)
 Age and sex RBC count r −0.362 −0.068 0.060 −0.634 −0.883 −0.750 −0.118 −0.725
P value 0.304 0.852 0.870 0.049 0.001 0.005 0.715 0.008
Haematocrit r 0.231 0.172 −0.086 − 0.918 − 0.555 − 0.418 0.273 − 0.718
P value 0.521 0.635 0.813 < 0.0001 0.061 0.176 0.391 0.009
Haemoglobin r −0.218 0.032 0.563 −0.616 − 0.526 − 0.220 0.521 − 0.792
P value 0.545 0.929 0.090 0.058 0.079 0.493 0.082 0.002
Sickle cell trait (HbAS) (n = 31) Sickle cell trait (HbAS) (n = 14)
 Age and sex RBC count r −0.299 −0.494 −0.434 − 0.292 − 0.752 −0.797 − 0.305 −0.392
P value 0.116 0.006 0.019 0.125 0.003 0.001 0.311 0.185
Haematocrit r 0.515 0.221 −0.458 −0.507 −0.269 −0.369 − 0.394 −0.506
P value 0.004 0.249 0.013 0.005 0.375 0.214 0.183 0.078
Haemoglobin r 0.547 0.533 0.069 −0.694 −0.247 −0.235 −0.080 − 0.475
P value 0.002 0.003 0.720 < 0.0001 0.417 0.441 0.796 0.101
Normal haemoglobin (HbAA) (n = 90) Normal haemoglobin (HbAA) (n = 58)
 Age and sex RBC count r −0.324 −0.273 −0.401 − 0.235 − 0.393 −0.408 − 0.270 −0.399
P value 0.002 0.010 < 0.0001 0.027 0.003 0.002 0.043 0.002
Haematocrit r 0.524 0.143 −0.333 −0.361 0.139 .076 −0.072 −0.446
P value < 0.0001 0.181 0.001 < 0.0001 0.302 0.573 0.593 0.001
Haemoglobin r 0.525 0.408 0.269 −0.664 0.257 0.317 0.285 −0.479
P value < 0.0001 < 0.0001 0.011 < 0.0001 0.053 0.016 0.032 0.001
  1. Data are the partial correlations (r). Malaria negative patients (n = 132) and malaria positive patients (n = 85) with acute febrile illness were categorized on the basis of haemoglobin type. All statistical significance was determined by the partial correlation test (r) controlling for age and sex. Values in bold are statistically significant at P ≤ 0.05
  2. Abbreviations: MCV Mean corpuscular volume, MCH mean corpuscular haemoglobin, MCHC mean corpuscular haemoglobin concentration, RBC-Red blood cells, RDW Red cell distribution width, r the measure of strength of Pearson’s correlation