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Table 1 General Demographic and Laboratory Characteristics of the Study Participants

From: Haematological abnormalities in children with sickle cell disease and non-severe malaria infection in western Kenya

All the study participants (Infected and non-infected) P. falciparum infected children based on genotype (n = 85)
Characteristics Non-Infected (n = 132) Infected (n = 85) P-value HbAA (n = 58) HBAS (n = 14) HbSS (n = 13) P-Value
Sex, n (%)
 Male 76 (57.6) 42 (49.4) 0.240a 30 (51.7) 7 (50) 8 (61.5) 0.690a
 Female 56 (42.4) 43 (50.6) 28 (48.3) 7 (50) 5 (38.5)  
Age, (months) 30 (48) 36 (55) 0.143b 36 (64.5) 36 (32.3) 16 (27) 0.660c
Haemoglobin type
 HbAA, n (%) 90 (68.2) 58 (68.2)      
 HbAS, n (%) 31 (23.5) 14 (16.5) 0.743a     
 HbSS, n (%) 11 (8.3) 13 (15.3)      
Haematological Parameters Haematological Parameters
 Haemoglobin, gdL−1 10.5 (2.3) 10.1 (3.1) 0.022b 10.2 (2.2) 10.4 (1.6) 7.3 (1.3) 0.001c
 Haematocrit, % 35.2 (6.8) 32.8 (9.0) 0.009b 34.6 (8.3) 32.8 (6.0) 26.4 (4.4) 0.009c
 RBC, (×  1012 μL−1) 4.8 (0.7) 4.6 (1.3) 0.045b 4.6 (1.0) 4.8 (1.5) 3.2 (1.7) 0.048c
 RDW, % 11.7 (3.0) 11.6 (2.8) 0.703b 11.3 (2.2) 11.5 (2.6) 14.9 (3.3) 0.030c
 MCV, fL 76.3 (11.4) 75.2 (10.9) 0.349b 75.2 (9.9) 74.1 (11.8) 79.5 (15.9) 0.415c
 MCH, fL/cell 22.7 (4.3) 22.5 (3.7) 0.744b 22.1 (3.7) 22.6 (4.0) 23.1 (3.5) 0.724c
 MCHC, gdL−1 29.6 (3.7) 29.8 (3.0) 0.479b 29.7 (2.5) 30.9 (1.7) 27.7 (4.1) 0.054c
 WBC (× 103 μL−1) 8.5 (6.0) 8.6 (5.2) 0.746b 7.8 (4.8) 9.58 (5.2) 12.68 (4.6) 0.078c
 Lymphocytes, (×103 μL−1) 44.1 (25.3) 38 (66.9) 0.103b 36.55 (27.2) 37 (36.2) 50.9 (29.1) 0.596c
 Monocytes, (×103 μL−1) 9.3 (4.4) 11.2 (7.2) 0.084b 11.2 (7.4) 12 (7.8) 8.1 (6.1) 0.282c
 Granulocytes, (×103 μL−1) 46.1 (26.3) 50.0 (25.8) 0.354b 51.4 (27.2) 48.9 (27.5) 39 (28.2) 0.494c
 Platelet Counts, (×103 μL−1) 278.0 (112.8) 236 (129.5) 0.001b 220 (1127) 233 (129) 236(140) 0.399c
 MPV, fL 5.5 (0.5) 5.40 (0.6) 0.119b 5.4 (0.6) 5.3 (0.9) 5.2 (0.8) 0.990c
 PCT, % 0.2 (0.1) 0.13 (0.1) 0.001b 0.13 (0.1) 0.14 (0.1) 0.12 (0.1) 0.772c
 PDW, % 9.4 (1.5) 9.5 (1.5) 0.629b 9.6 (1.4) 9.5 (2.0) 9.5 (0.40) 0.951c
  1. Data are presented as the median (interquartile range; IQR) values unless stated otherwise. Study participants were categorized into non-infected and infected (with any density parasitaemia). a Statistical significance was determined by the Chi-square (χ2) analysis. b Statistical significance was determined using Mann- Whitney test. c Statisitical significance determined by the Kruskal-Wallis test
  2. Abbreviations: HbAA Normal haemoglobin, HbAS Heterozygous sickle cell trait, HbSS Homozygous Haemoglobin S, MCV Mean corpuscular volume, MCH mean corpuscular haemoglobin, MCHC mean corpuscular haemoglobin concentration, WBC White blood cell count, RBC Red blood cells, RDW Red cell distribution width, MPV mean platelet volume, PCT Plateletcrit, PDW Platelet distribution width
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