Skip to main content

Table 1 General Demographic and Laboratory Characteristics of the Study Participants

From: Haematological abnormalities in children with sickle cell disease and non-severe malaria infection in western Kenya

All the study participants (Infected and non-infected)

P. falciparum infected children based on genotype (n = 85)

Characteristics

Non-Infected (n = 132)

Infected (n = 85)

P-value

HbAA (n = 58)

HBAS (n = 14)

HbSS (n = 13)

P-Value

Sex, n (%)

 Male

76 (57.6)

42 (49.4)

0.240a

30 (51.7)

7 (50)

8 (61.5)

0.690a

 Female

56 (42.4)

43 (50.6)

28 (48.3)

7 (50)

5 (38.5)

 

Age, (months)

30 (48)

36 (55)

0.143b

36 (64.5)

36 (32.3)

16 (27)

0.660c

Haemoglobin type

 HbAA, n (%)

90 (68.2)

58 (68.2)

     

 HbAS, n (%)

31 (23.5)

14 (16.5)

0.743a

    

 HbSS, n (%)

11 (8.3)

13 (15.3)

     

Haematological Parameters

Haematological Parameters

 Haemoglobin, gdL−1

10.5 (2.3)

10.1 (3.1)

0.022b

10.2 (2.2)

10.4 (1.6)

7.3 (1.3)

0.001c

 Haematocrit, %

35.2 (6.8)

32.8 (9.0)

0.009b

34.6 (8.3)

32.8 (6.0)

26.4 (4.4)

0.009c

 RBC, (×  1012 μL−1)

4.8 (0.7)

4.6 (1.3)

0.045b

4.6 (1.0)

4.8 (1.5)

3.2 (1.7)

0.048c

 RDW, %

11.7 (3.0)

11.6 (2.8)

0.703b

11.3 (2.2)

11.5 (2.6)

14.9 (3.3)

0.030c

 MCV, fL

76.3 (11.4)

75.2 (10.9)

0.349b

75.2 (9.9)

74.1 (11.8)

79.5 (15.9)

0.415c

 MCH, fL/cell

22.7 (4.3)

22.5 (3.7)

0.744b

22.1 (3.7)

22.6 (4.0)

23.1 (3.5)

0.724c

 MCHC, gdL−1

29.6 (3.7)

29.8 (3.0)

0.479b

29.7 (2.5)

30.9 (1.7)

27.7 (4.1)

0.054c

 WBC (× 103 μL−1)

8.5 (6.0)

8.6 (5.2)

0.746b

7.8 (4.8)

9.58 (5.2)

12.68 (4.6)

0.078c

 Lymphocytes, (×103 μL−1)

44.1 (25.3)

38 (66.9)

0.103b

36.55 (27.2)

37 (36.2)

50.9 (29.1)

0.596c

 Monocytes, (×103 μL−1)

9.3 (4.4)

11.2 (7.2)

0.084b

11.2 (7.4)

12 (7.8)

8.1 (6.1)

0.282c

 Granulocytes, (×103 μL−1)

46.1 (26.3)

50.0 (25.8)

0.354b

51.4 (27.2)

48.9 (27.5)

39 (28.2)

0.494c

 Platelet Counts, (×103 μL−1)

278.0 (112.8)

236 (129.5)

0.001b

220 (1127)

233 (129)

236(140)

0.399c

 MPV, fL

5.5 (0.5)

5.40 (0.6)

0.119b

5.4 (0.6)

5.3 (0.9)

5.2 (0.8)

0.990c

 PCT, %

0.2 (0.1)

0.13 (0.1)

0.001b

0.13 (0.1)

0.14 (0.1)

0.12 (0.1)

0.772c

 PDW, %

9.4 (1.5)

9.5 (1.5)

0.629b

9.6 (1.4)

9.5 (2.0)

9.5 (0.40)

0.951c

  1. Data are presented as the median (interquartile range; IQR) values unless stated otherwise. Study participants were categorized into non-infected and infected (with any density parasitaemia). a Statistical significance was determined by the Chi-square (χ2) analysis. b Statistical significance was determined using Mann- Whitney test. c Statisitical significance determined by the Kruskal-Wallis test
  2. Abbreviations: HbAA Normal haemoglobin, HbAS Heterozygous sickle cell trait, HbSS Homozygous Haemoglobin S, MCV Mean corpuscular volume, MCH mean corpuscular haemoglobin, MCHC mean corpuscular haemoglobin concentration, WBC White blood cell count, RBC Red blood cells, RDW Red cell distribution width, MPV mean platelet volume, PCT Plateletcrit, PDW Platelet distribution width