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Table 3 Mutations conferring antibiotices resistance

From: Molecular characterization of multidrug-resistant tuberculosis against levofloxacin, moxifloxacin, bedaquiline, linezolid, clofazimine, and delamanid in southwest of China

Gene Nucleotide Substitution Amino acid change ATB drug Number of isolates
gyrA G262T Gly88Cys LFX 1
MXF 1
G265A Asp89Asn LFX 1
MXF 1
C269T Ala90Val LFX 8
MXF 6
T271C Ser91Pro LFX 1
MXF 1
G280T Asp94Tyr LFX 11
MXF 11
G280A Asp94Asn LFX 4
MXF 4
A281C Asp94Ala LFX 6
MXF 5
A281G Asp94Gly LFX 13
MXF 9
G284C Ser95Thr LFX 44
MXF 34
Rv0678 A152G Gln31Arg BDQ 1
CFZ 1
T157C Ser53Pro BDQ 1
CFZ 1
rplC T460C Cys154Arg LZD 2
ddn G241A Gly81Ser DMD 2
fbiC G952A Val318Ile DMD 1