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Table 4 Multivariable predictive model for 30-day mortality: Clinical variables, and added predictive value of day 4 cytokines

From: Cytokine measurements add value to clinical variables in predicting outcomes for Staphylococcus aureus bacteremia

Model (Sample Size) Odds Ratio
(95% CI)
p-value AUC
(95% CI)
p-value for AUC difference from clinical model
Clinical variable model (576)
 CAD 2.93 (1.42, 6.08) 0.004   
 Septic shock at onset of SAB 4.92 (2.35, 10.29) < 0.0001   
 PBS ≥4 (vs. < 4) 5.44 (2.67, 11.09) < 0.0001   
    0.804 (0.735, 0.873)
Added Day 4 cytokine variables individually as quartiles a:
TNFα (581)    0.879 (0.838, 0.920) 0.0003
  Q1: < 6.73 Ref    
  Q2: 6.73–12.57 6.89 (0.77, 61.75) 0.73   
  Q3: 12.58–24.67 21.63 (2.69, 173.82) < 0.01   
  Q4: > 24.67 27.7 (3.52, 217.73) 0.0003   
IL-10 (531)    0.873 (0.817, 0.930) 0.003
  Q1: < 5.49 Ref    
  Q2: 5.49–13.57 1.71 (0.41, 7.24) 0.32   
  Q3: 13.58–28.93 2.38 (0.63, 8.92) 0.82   
  Q4: > 28.93 10.74 (3.28, 35.14) < 0.0001   
IL-6 (513)    0.828 (0.765, 0.892) 0.03
  Q1: < 7.02 Ref    
  Q2: 7.02–19.93 1.53 (0.34, 6.98) 0.21   
  Q3: 19.94–57.20 4.12 (1.07, 15.91) 0.12   
  Q4: > 57.20 6.45 (1.74, 23.97) 0.001   
IL-8 (510)    0.846 (0.783, 0.908) 0.01
  Q1: < 12.94 Ref    
  Q2: 12.94–28.05 0.59 (0.10, 3.54) 0.03   
  Q3: 28.06–68.95 3.51 (0.10, 12.34) 0.11   
  Q4: > 68.95 7.87 (2.40, 25.82) < 0.0001   
  1. aOnly included cytokines contributing significant prediction beyond clinical variable model; Q quartile, Ref reference