Skip to main content

Table 3 Multivariable predictive model for persistence: Clinical variables alone and added predictive value of day 1 cytokines

From: Cytokine measurements add value to clinical variables in predicting outcomes for Staphylococcus aureus bacteremia

Model (Sample Size) Odds Ratio (95% CI) p-value AUC (95% CI) p-value for AUC difference from clinical model
Clinical variable model (239)
 Septic shock at onset of SAB 4.09 (1.826, 9.173) < 0.001 0.601 (0.537, 0.664)
Added Day 1 cytokine variables individually as quartiles a:
TNFα (239)    0.714 (0.635, 0.794) 0.0005
  Q1: < 9.54 Ref    
  Q2: 9.54–18.96 1.92 (0.6, 6.142) 0.27   
  Q3: 18.97–36.85 2.79 (0.918, 8.475) 0.07   
  Q4: > 36.85 6.79 (2.334, 19.758) 0.0004   
IL-10 (228)    0.708 (0.629, 0.788) 0.001
  Q1: < 11.11 Ref    
  Q2: 11.11–29.96 1.92 (0.599, 6.139) 0.27   
  Q3: 29.97–118.22 3.80 (1.274, 11.271) 0.02   
  Q4: > 118.22 4.53 (1.487, 13.808) < 0.01   
IL-8 (184)    0.666 (0.568, 0.765) 0.02
  Q1: < 18.00 Ref    
  Q2: 18.00–48.10 1.27 (0.369, 4.372) 0.70   
  Q3: 48.11–128.56 2.09 (0.642, 6.802) 0.22   
  Q4: > 128.56 3.60 (1.163, 11.123) 0.03   
IL-6 (182)    0.600 (0.486–0.715) 0.53
  Q1: < 25.92 Ref    
  Q2: 25.92–69.56 0.22 (0.064, 0.745) 0.02   
  Q3: 69.57–222.65 0.44 (0.157, 1.235) 0.12   
  Q4: > 222.65 0.72 (0.27, 1.912) 0.51   
  1. aOnly included cytokines contributing significant prediction beyond clinical variable model; Q quartile, Ref reference