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Table 2 Quartile values of cytokine measurements on Day 1 and Day 4 of SAB

From: Cytokine measurements add value to clinical variables in predicting outcomes for Staphylococcus aureus bacteremia

Cytokine (pg/ml) Quartile 1 Quartile 2 Quartile 3 Quartile 4 Overall
p-value
Persistence
Overall
p-value
Mortality
TNF
 Day 1 < 9.54 9.54–18.96 18.97–36.85 > 36.85 < 0.0001  
 Day 4 < 6.73 6.73–12.57 12.58–24.67 > 24.67   < 0.0001
IL-10
 Day 1 < 11.11 11.11–29.96 29.97–118.22 > 118.22 0.002  
 Day 4 < 5.49 5.49–13.57 13.58–28.93 > 28.93   < 0.0001
IL-6
 Day 1 < 25.92 25.92–69.56 69.57–222.65 > 222.65 0.10  
 Day 4 < 7.02 7.02–19.93 19.94–57.20 > 57.20   0.001
IL-8
 Day 1 < 18.00 18.00–48.10 48.11–128.56 > 128.56 0.06  
 Day 4 < 12.94 12.94–28.05 28.06–68.95 > 68.95   < 0.0001
IFNγ
 Day 1 < 4.34 4.34–9.13 9.14–18.69 > 18.69 0.19  
 Day 4  < 3.45 3.45–7.00 7.01–13.25 > 13.25   0.69
IL-1β
 Day 1 < 1.21 1.21–2.77 2.78–3.25 > 3.25 0.50  
 Day 4 < 0.83 0.83–1.84 1.85–3.64 > 3.64   0.87
IL-17
 Day 1 < 1.92 1.92–5.07 5.08–11.22 > 11.22 0.17  
 Day 4 < 1.88 1.88–3.75 3.76–9.88 > 9.88   0.23
  1. All cytokine concentrations (IFNγ, IL-1β, IL-6, IL-8, IL-10, IL-17, TNF) were measured in duplicates using Luminex multiplex assay (Millipore, Billerica, MA) per manufacturer’s instructions. Chi-square (or Fisher’s exact) tests were performed on Day 1 cytokine measurements for persistence and Day 4 measurements for mortality, respectively