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Fig. 1 | BMC Infectious Diseases

Fig. 1

From: Optimal empiric treatment for KPC-2-producing Klebsiella pneumoniae infections in critically ill patients with normal or decreased renal function using Monte Carlo simulation

Fig. 1

Simulated median and 95% prediction interval of FOS, CMS and TGC concentrations in serum in male patients with normal renal function: a FOS 4 g q8h; b FOS 6 g q8h; c FOS 8 g q8h; d CMS 9 MIU loading. Dose followed by 3 million IU q12h; e TGC 100 mg loading dose followed by 50 mg q12h; f 100 mg loading dose followed by 50 mg q12h; g 400 mg loading dose followed by 200 mg q24h; h 9 million IU loading dose followed by 4.5 million IU q12h. Black soid line, simulated median concentrations of drugs; red dotted line, 95% prediction interval concentrations of drugs. FOS, fosfomycin; CMS, colistin methanesulfonate; TGC, tigecycline

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