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Table 3 Univariate and multivariate analyses showing significant predictive factors of overall mortality (n = 1252)

From: Impact of acute kidney injury on survival in patients with chronic hepatitis C: a retrospective cohort study

Variable

Univariate analysis

Multivariate analysis

P

HR (95% CI)

P

HR (95% CI)

Male

0.007

1.63 (1.14–2.34)

0.097

1.38 (0.94–2.00)

Age per year

< 0.001

1.03 (1.02–1.05)

0.813

1.00 (0.99–1.02)

Platelet per 109/L

< 0.001

0.99 (0.98–0.99)

0.590

0.99 (0.99–1.01)

MELD score per point

< 0.001

1.17 (1.14–1.20)

0.126

1.06 (0.98–1.14)

Child-Pugh score per point

< 0.001

1.85 (1.67–2.05)

0.436

1.08 (0.89–1.30)

SVR

< 0.001

0.13 (0.08–0.22)

< 0.001

0.33 (0.19–0.59)

Extrahepatic malignancy

< 0.001

3.96 (2.35–6.69)

< 0.001

4.25 (2.64–6.82)

CH (diagnosis at entry)

Reference

Reference

 Com-LC

< 0.001

2.69 (1.60–4.53)

0.108

1.60 (0.90–2.84)

 Decom-LC or HCC

< 0.001

12.13 (8.27–17.79)

< 0.001

5.63 (3.39–9.37)

AKI

< 0.001

13.60 (8.92–20.73)

< 0.001

6.66 (4.26–10.41)

  1. Abbreviations: HR Hazard ratio, CI Confidence interval, MELD score Model for end-stage liver disease score, SVR Sustained virologic response, Com-LC Compensated cirrhosis, Decom-LC Decompensated cirrhosis, HCC Hepatocellular carcinoma, AKI Acute kidney injury