From: Early prediction of blood stream infection in a prospectively collected cohort
Whole cohort n = 484 (positive blood cultures n = 84 (17%)) | Patients fulfilling Sepsis-3 criteria n = 155 (positive blood cultures n = 32 (21%)) | |||||||||||
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Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | LR+ | LR- | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | LR+ | LR- | |
NLCR > 10 | 74 (64–83) | 60 (55–65) | 28 (25–32) | 92 (88–94) | 1.9 (1.6–2.2) | 0.4 (0.3–0.6) | 77 (59–90) | 43 (35–53) | 26 (21–31) | 88 (79–94) | 1.4 (1.1–1.7) | 0.5 (0.3–1.0) |
NLCR > 12 | 67 (56–77) | 68 (64–73) | 31 (27–36) | 91 (88–93) | 2.1 (1.7–2.6) | 0.5 (0.4–0.7) | 65 (45–81) | 57 (48–66) | 28 (22–35) | 86 (79–91) | 1.5 (1.1–2.1) | 0.6 (0.4–1.0) |
MSS ≥ 2 | 86 (76–92) | 38 (33–43) | 23 (21–25) | 93 (88–96) | 1.4 (1.2–1.6) | 0.4 (0.2–0.6) | 94 (79–99) | 24 (17–33) | 24 (22–27) | 94 (79–98) | 1.2 (1.1–1.4) | 0.3 (0.1–1.0) |
MSS ≥ 3 | 69 (58–78) | 64 (59–69) | 29 (25–33) | 91 (88–93) | 1.9 (1.6–2.3) | 0.5 (0.3–0.7) | 81 (64–93) | 46 (37–56) | 28 (24–33) | 91 (82–95) | 1.5 (1.2–1.9) | 0.4 (0.2–0.9) |
NLCR> 12 and MSS ≥ 3 | 48 (36–59) | 84 (80–88) | 39 (32–47) | 88 (86–90) | 3.0 (2.2–4.2) | 0.6 (0.5–0.8) | 52 (33–70) | 73 (64–81) | 33 (24–43) | 86 (80–90) | 1.9 (1.2–3.0) | 0.7 (0.5–1.0) |