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Table 4 Sensitivity, specificity, positive (PPV) and negative (NPV) predictive values and positive (LR+) and negative (LR-) likelihood ratios for predicting positive blood culture using cut-off values of Neutrophil-lymphocyte count ratio (NLCR) and modified Shapiro score (MSS) suggested previously and based on the data presented in this study. Values presented in the whole cohort and among patients fulfilling sepsis-3 criteria. 95% confidence interval presented within brackets. Data for patients not fulfilling sepsis-3 criteria are presented in Supplementary Table 3

From: Early prediction of blood stream infection in a prospectively collected cohort

  Whole cohort n = 484 (positive blood cultures n = 84 (17%)) Patients fulfilling Sepsis-3 criteria n = 155 (positive blood cultures n = 32 (21%))
Sensitivity (%) Specificity (%) PPV (%) NPV (%) LR+ LR- Sensitivity (%) Specificity (%) PPV (%) NPV (%) LR+ LR-
NLCR > 10 74 (64–83) 60 (55–65) 28 (25–32) 92 (88–94) 1.9 (1.6–2.2) 0.4 (0.3–0.6) 77 (59–90) 43 (35–53) 26 (21–31) 88 (79–94) 1.4 (1.1–1.7) 0.5 (0.3–1.0)
NLCR > 12 67 (56–77) 68 (64–73) 31 (27–36) 91 (88–93) 2.1 (1.7–2.6) 0.5 (0.4–0.7) 65 (45–81) 57 (48–66) 28 (22–35) 86 (79–91) 1.5 (1.1–2.1) 0.6 (0.4–1.0)
MSS ≥ 2 86 (76–92) 38 (33–43) 23 (21–25) 93 (88–96) 1.4 (1.2–1.6) 0.4 (0.2–0.6) 94 (79–99) 24 (17–33) 24 (22–27) 94 (79–98) 1.2 (1.1–1.4) 0.3 (0.1–1.0)
MSS ≥ 3 69 (58–78) 64 (59–69) 29 (25–33) 91 (88–93) 1.9 (1.6–2.3) 0.5 (0.3–0.7) 81 (64–93) 46 (37–56) 28 (24–33) 91 (82–95) 1.5 (1.2–1.9) 0.4 (0.2–0.9)
NLCR> 12 and MSS ≥ 3 48 (36–59) 84 (80–88) 39 (32–47) 88 (86–90) 3.0 (2.2–4.2) 0.6 (0.5–0.8) 52 (33–70) 73 (64–81) 33 (24–43) 86 (80–90) 1.9 (1.2–3.0) 0.7 (0.5–1.0)