All (n = 1368) | COVID-19a (n = 496) | Alternative diagnosis (n = 872) | P-value‡ | |
---|---|---|---|---|
Age, years | 68 (53, 80) | 71 (57, 82) | 67 (51, 78) | < 0.001 |
Sex | 0.078 | |||
Men | 731 (53%) | 281 (57%) | 450 (52%) | |
Women | 637 (47%) | 215 (43%) | 422 (48%) | |
Ethnicity | 0.83 | |||
White | 1087 (97%) | 372 (97%) | 715 (98%) | |
Other | 29 (2.6%) | 11 (2.9%) | 18 (2.5%) | |
Deprivationb | 0.002 | |||
1 (most deprivation) | 239 (18%) | 65 (13%) | 174 (20%) | |
2 | 321 (24%) | 116 (24%) | 205 (24%) | |
3 | 236 (17%) | 79 (16%) | 157 (18%) | |
4 | 243 (18%) | 93 (19%) | 150 (17%) | |
5 (least deprivation) | 319 (23%) | 139 (28%) | 180 (21%) | |
Duration of symptoms, days | 3.0 [1.0–5.0] | 3.0 [2.0–7.0] | 2.0 [1.0–4.0] | < 0.001 |
Clinical features | ||||
Fever | 691 (51%) | 322 (65%) | 369 (42%) | < 0.001 |
Upper respiratory tract symptoms | 141 (10%) | 63 (13%) | 78 (9%) | 0.034 |
Lower respiratory tract symptoms | 891 (65%) | 419 (85%) | 472 (54%) | < 0.001 |
Systemic symptoms | 501 (37%) | 257 (52%) | 244 (28%) | < 0.001 |
Neurological symptoms | 309 (23%) | 118 (24%) | 191 (22%) | 0.45 |
Gastrointestinal symptoms | 316 (23%) | 107 (22%) | 209 (24%) | 0.36 |
Lymphopenia | 894 (65%) | 406 (82%) | 488 (56%) | < 0.001 |
Inflammation | 986 (72%) | 421 (86%) | 565 (65%) | < 0.001 |
Radiological signs | 409 (30%) | 316 (64%) | 93 (11%) | < 0.001 |
Comorbidities | ||||
Diabetes mellitus | 251 (18%) | 96 (19%) | 155 (18%) | 0.51 |
Ischemic heart disease | 136 (10%) | 45 (9.1%) | 91 (11%) | 0.44 |
Heart failure | 112 (8.3%) | 38 (7.7%) | 74 (8.6%) | 0.62 |
Stroke | 82 (6.0%) | 27 (5.4%) | 55 (6.3%) | 0.60 |
COPD | 206 (15%) | 58 (12%) | 148 (17%) | 0.011 |
Asthma | 113 (8.3%) | 30 (6.0%) | 83 (9.5%) | 0.033 |
Liver cirrhosis | 27 (2.0%) | 8 (1.6%) | 19 (2.2%) | 0.60 |
End stage kidney disease | 25 (1.8%) | 12 (2.4%) | 13 (1.5%) | 0.31 |
Medications at presentation | ||||
ACE inhibitors or ARBs | 336 (25%) | 129 (26%) | 207 (24%) | 0.38 |
Corticosteroids | 223 (16%) | 73 (15%) | 150 (17%) | 0.27 |
Immunosuppressants | 34 (2.5%) | 15 (3.0%) | 19 (2.2%) | 0.43 |