Table 2 Diagnosis, treatment and prognosis of neonatal meningitis caused by U. parvum
Author, year | Identification | CSF parameters (before treatment for U. parvum meningitis) | Treatment | Prognosis | |||
|---|---|---|---|---|---|---|---|
Leukocytes (ul) | Protein (g/l) | Glucose (mmol/l) | |||||
Clifford V et al., 2010 [11] | PCR | 76 (18 polymorphonuclear cells and 58 lymphocytes) | 2.86 | < 1.2 | ERY (30 mg/kg/d) × 3 d → ERY + CIP (20 mg/kg/d) × 3 weeks | VP shunt | developed appropriately at the age of 6 months |
Biran V et al., 2010 [12] | PCR and culture | 1610 (86% polymorphonuclear) | 5.2 | 0.1 | CIP × 7 weeks + THI × 3 weeks | VP shunt | developed appropriately at the age of 8 and 14 months |
Glaser K et al., 2014 | PCR | 50–86 (60% lymphocytes) | 5.78–10.26 | undetectable | CAM × 2d → CHL × 3 weeks | VP shunt | recovered from severe developmental delay (tendon reflexes were improved), being able to sit unaided, to walk with little assistance and to comprehend simple linguistic requests at 16 month adjusted age |
Keus AMJMH et al., 2019 [13] | PCR | 1387 | NA | NA | ERY (30 mg/kg/d) + CIP (20–25 mg/kg/d) × 5 weeks → AZI (12 mg/kg/d) + CIP (25 mg/kg/d) × 1 weeks | NA | normal age-related development at the age of 30 months |
Wang Q et al., 2020 [14] | mNGS and PCR | 880 (48% of neutrophils) | 2.6 | < 1.11 | ERY (10 mg/kg/dose q6 h) × 4 weeks | NA | developed well without abnormal neurological signs during the follow-up until 18 months old. Hydrocephalus was improved at the age of 6 months. |
Our case | mNGS and culture | 1135–1319 (60–88% lymphocytes) | 1.36–2.259 | 0.45–1.21 | ERY (30 mg/kg/d) × 5 weeks | removal of subdural hematoma | developed well without abnormal neurological signs during the follow-up at 5 months old |