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Table 6 Summary of C-reactive protein association studies with bacteraemia

From: C-reactive protein predicts complications in community-associated S. aureus bacteraemia: a cohort study

StudyFirst Author Setting Population Cut-off [mg/L] Poor outcome [Ref].
Horino RetrospectiveSingle centre n = 73 AdultMSSA-SAB > 30.0 Metastatic infection [50]
Holmes Prospective Multi-centren = 222 Adult SAB > 250.0 30-day Treatment failure [32]
Pravin ProspectiveCross-sectional Single centren = 75 Neonates,All-causeSepsis symptoms > 30.0 Sepsis [51]
Bernstein Retrospective, Single centren = 109 PaediatricS. aureusSeptic arthritis > 13.7 MRSA Septic arthritis [52]
Bouchard Retrospective, Single centren = 183 PaediatricAll-causeSeptic arthritis < 20.0 Not reliable as a marker for clearance of infection [53]
Tascini RetrospectiveMulti-centren = 236 AdultAll-cause Infective endocarditis > 130.0> 850.0 -S. aureus infective endocarditis-Death [54]
Molkanen ProspectiveMulti-centren = 430 Adult SAB Day 4: > 103.0Day 14: > 61.0Day of diagnosis: > 108.0Day 14: > 22.0 -death-death-deep infection-deep infection [55]
Lin RetrospectiveSingle centren = 108 All ages,All-cause Osteomyelitis > 5.0> 8.0 -Prosthesis related-osteomyelitis recurrence-Prosthesis unrelated-osteomyelitis recurrence [56]
Chiappini RetrospectiveSingle centren = 121 PaediatricAll-causeAcute haematogenous osteomyelitis > 10.0 Complicated acute haematogenous osteomyelitis [57]
Tang RetrospectiveSingle centren = 825 AdultAll-cause bacteraemia No cut-off Distinguishes positive and negative cultures,Distinguishes between gram positive, negative and candidaDistinguishes between species [58]
Garcia del Pozo RetrospectiveSingle centren = 116 AdultAll-causeLong boneosteomyelitis NA Relapse recurrent osteomyelitis [59]
Botheras ProspectiveSingle centren = 158 Adult community-onset SAB > 161.0 Complicated SAB  
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