Table 6 Summary of C-reactive protein association studies with bacteraemia
StudyFirst Author | Setting | Population | Cut-off [mg/L] | Poor outcome | [Ref]. |
|---|---|---|---|---|---|
Horino | RetrospectiveSingle centre n = 73 | AdultMSSA-SAB | > 30.0 | Metastatic infection | [50] |
Holmes | Prospective Multi-centren = 222 | Adult SAB | > 250.0 | 30-day Treatment failure | [32] |
Pravin | ProspectiveCross-sectional Single centren = 75 | Neonates,All-causeSepsis symptoms | > 30.0 | Sepsis | [51] |
Bernstein | Retrospective, Single centren = 109 | PaediatricS. aureusSeptic arthritis | > 13.7 | MRSA Septic arthritis | [52] |
Bouchard | Retrospective, Single centren = 183 | PaediatricAll-causeSeptic arthritis | < 20.0 | Not reliable as a marker for clearance of infection | [53] |
Tascini | RetrospectiveMulti-centren = 236 | AdultAll-cause Infective endocarditis | > 130.0> 850.0 | -S. aureus infective endocarditis-Death | [54] |
Molkanen | ProspectiveMulti-centren = 430 | Adult SAB | Day 4: > 103.0Day 14: > 61.0Day of diagnosis: > 108.0Day 14: > 22.0 | -death-death-deep infection-deep infection | [55] |
Lin | RetrospectiveSingle centren = 108 | All ages,All-cause Osteomyelitis | > 5.0> 8.0 | -Prosthesis related-osteomyelitis recurrence-Prosthesis unrelated-osteomyelitis recurrence | [56] |
Chiappini | RetrospectiveSingle centren = 121 | PaediatricAll-causeAcute haematogenous osteomyelitis | > 10.0 | Complicated acute haematogenous osteomyelitis | [57] |
Tang | RetrospectiveSingle centren = 825 | AdultAll-cause bacteraemia | No cut-off | Distinguishes positive and negative cultures,Distinguishes between gram positive, negative and candidaDistinguishes between species | [58] |
Garcia del Pozo | RetrospectiveSingle centren = 116 | AdultAll-causeLong boneosteomyelitis | NA | Relapse recurrent osteomyelitis | [59] |
Botheras | ProspectiveSingle centren = 158 | Adult community-onset SAB | > 161.0 | Complicated SAB | Â |