Table 5 Association between any drug sensitivity patterns and TB type, major lineage, sub-lineage and dominant strains
Variable | Any drug resistance | ||||
|---|---|---|---|---|---|
Sensitive (%) | Resistant (%) | Total (%) | χ2 (df) | P- value | |
TB type | |||||
Extra-pulmonary | 10 (76.9%) | 3 (23.1%) | 13 (14%) | 0.233 (1) | 0.629 |
pulmonary | 66 (82.5%) | 14 (17.5%) | 80 (86%) | ||
Major lineage by CBN | |||||
EA | 47 (79.7%) | 12 (20.3%) | 59 (63.4%) | 0.757 (2) | 0.757 |
IO | 15 (83.3%) | 3 (16.7%) | 17 (19.4%) | ||
EAI | 14 (87.5%) | 2 (12.5%) | 16 (17.2%) | ||
Sub-lineage/Clade | |||||
AFRI | 4 (100%) | 0 | 4 (4.3%) | ||
CAS | 3 (100%) | 0 | 3 (3.4%) | ||
CAS1-Delhi | 12 (100%) | 0 | 12 (12.8%) | ||
CAS1-Kili | 2 (40.0%) | 3 (60.0%) | 5 (5.3%) | ||
EAI1-SOM | 1 (100%) | 0 | 1 (1.1%) | ||
H | 3 (100%) | 0 | 3 (3.4%) | ||
H1 | 0 | 2 (100%) | 2 (2.1%) | ||
H3 | 2 (66.7%) | 1 (33.3%) | 3 (3.4%) | ||
H3-Ural-1 | 1 (100%) | 0 | 1 (1.1%) | ||
H37Rv | 1 (100%) | 0 | 1 (1.1%) | ||
H4-Ural-2 | 3 (100%) | 0 | 3 (3.4%) | ||
Manu_ancestor | 0 | 1 (100%) | 1 (1.1%) | 34.861(22) | 0.040 |
Manu1 | 3 (75%) | 1 (25%) | 4 (4.3%) | ||
Manu2 | 6 (75%) | 2 (25%) | 8 (8.5%) | ||
Manu3 | 7 (70%) | 3 (30%) | 10 (10.6%) | ||
PINI | 1 (100%) | 0 | 1 (1.1%) | ||
T | 17 (94.4%) | 1 (5.6%) | 18 (19.1%) | ||
T-Tuscany | 1 (100%) | 0 | 1 (1.1%) | ||
T1-RUS2 | 0 | 1 (100%) | 1 (1.1%) | ||
T3 | 1 (100%) | 0 | 1 (1.1%) | ||
T3-ETH | 6 (85.7%) | 1 (14.3%) | 7 (7.4%) | ||
T4 | 2 (66.7%) | 1 (33.3%) | 3 (3.4%) | ||
Turkey | 1 (100%) | 0 | 1 (1.1%) | ||
Dominant strains | |||||
Orphan | 66 (86.8%) | 13 (76.5%) | 79 (84.9%) | ||
SIT1166 | 1 (1.3%) | 0 (0.0%) | 1 (1.1%) | ||
SIT1251 | 1 (1.3%) | 0 (0.0%) | 1 (1.1%) | ||
SIT1378 | 1 (1.3%) | 1 (5.9%) | 2 (2.2%) | ||
SIT1475 | 1 (1.3%) | 0 (0.0%) | 1 (1.1%) | 16.948(10) | 0.076 |
SIT149 | 3 (3.9%) | 0 (0.0%) | 3 (3.2%) | ||
SIT1547 | 1 (1.3%) | 0 (0.0%) | 1 (1.1%) | ||
SIT1802 | 0 (0.0%) | 1 (5.9%) | 1 (1.1%) | ||
SIT47 | 0 (0.0%) | 1 (5.9%) | 1 (1.1%) | ||
SIT53 | 2 (2.6%) | 0 (0.0%) | 2 (2.2%) | ||
SIT612 | 0 (0.0%) | 1 (5.9%) | 1 (1.1%) | ||
Clustering | |||||
Yes | 10 (62.5%) | 6 (37.5%) | 16 (17.2) | 4.779 (1) | 0.029 |
No | 66 (85.7%) | 11 (14.3%) | 77 (82.8) | ||