Fig. 3

Two-way scatter plots and linear regression predictions of 95% UDOI and SNP difference. a Two-way scatter plot of 95% UDOI and SNP difference between case pairs, and b) linear regression prediction of 95% UDOI and SNP difference with confidence interval. There is a statistically significant negative association between UDOI and SNP difference (Coef = − 2.59, P < 0.001). Note UDOI is logit transformed to reduce variable skew for regression modelling. Panel c and d exclude case pairs with no overlap