Table 2 Main outcomes for the primary, secondary, sensitivity and negative outcome analyses
| Â | Primary Analysis | Sensitivity Analysis | Primary Analysis | Sensitivity Analysis | ||||
|---|---|---|---|---|---|---|---|---|
ACE-I | CCB | ACE-I +/− CCB | CCB | ARB | CCB | ARB +/− CCB | CCB | |
Suspected or confirmed COVID-19 | ||||||||
 Propensity score matched analysis | ||||||||
  Outcome events, n (%) | 83 (0.44) | 85 (0.45) | 108 (0.45) | 108 (0.45) | 79 (0.74) | 58 (0.55) | 88 (0.66) | 75 (0.57) |
  Person-years | 8923 | 8932 | 11,211 | 11,219 | 5010 | 5016 | 6258 | 6267 |
  Crude incidence rate/1000 person-years | 9.30 | 9.52 | 9.63 | 9.63 | 15.77 | 11.56 | 14.06 | 11.97 |
  Unadjusted incidence rate ratio (95% CI) | 0.98 (0.72–1.32) p = 0.885 | 1.00 (0.77–1.31) p = 0.994 | 1.36 (0.97–1.91) p = 0.072 | 1.18 (0.86–1.60) p = 0.304 | ||||
  Adjusted hazard ratio (95% CI) | 0.92 (0.68–1.26) p = 0.609 | 0.95 (0.72–1.24) p = 0.703 | 1.38 (0.98–1.95) p = 0.062 | 1.18 (0.86–1.61) p = 0.303 | ||||
All-cause mortality | ||||||||
 Propensity score matched Analysis | ||||||||
  Outcome events, n (%) | 102 (0.54) | 66 (0.35) | 131 (0.55) | 109 (0.46) | 40 (0.38) | 50 (0.47) | 55 (0.41) | 70 (0.53) |
  Person-years | 8941 | 8950 | 11,234 | 11,242 | 5028 | 5028 | 6278 | 6282 |
  Crude incidence rate/1000 person years | 11.41 | 7.37 | 11.66 | 9.70 | 7.96 | 9.94 | 8.76 | 11.14 |
  Unadjusted incidence rate ratio (95% CI) | 1.55 (1.14–2.11) p = 0.006 | 1.20 (0.93–1.55) p = 0.155 | 0.80 (0.53–1.21) p = 0.293 | 0.79 (0.55–1.12) p = 0.182 | ||||
  Adjusted hazard ratio (95% CI) | 1.25 (0.90–1.73) p = 0.182 | 1.00 (0.77–1.30) p = 0.977 | 0.85 (0.56–1.30) p = 0.458 | 0.76 (0.53–1.09) p = 0.138 | ||||
Negative Control Outcome (Trauma/Accidents/Injury) | ||||||||
 PS Matched Analysis | ||||||||
  Outcome events, n (%) | 185 (0.98) | 187 (0.99) | 246 (1.04) | 246 (1.04) | 105 (0.99) | 108 (1.02) | 137 (1.03) | 146 (1.10) |
  Person-years | 8898 | 8904 | 11,176 | 11,182 | 5004 | 5002 | 6245 | 6246 |
  Crude incidence rate/1000 person years | 20.79 | 21.00 | 22.01 | 22.00 | 20.98 | 21.59 | 21.94 | 23.37 |
  Unadjusted incidence rate ratio (95% CI) | 0.99 (0.81–1.21) p = 0.923 | 1.00 (0.84–1.19) p = 0.996 | 0.97 (0.74–1.27) p = 0.835 | 0.94 (0.74–1.18) p = 0.594 | ||||
  Adjusted hazard ratio (95% CI) | 0.95 (0.77–1.17) p = 0.640 | 0.96 (0.80–1.14) p = 0.620 | 0.97 (0.74–1.27) p = 0.801 | 0.91 (0.72–1.15) p = 0.439 | ||||