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Table 2 Main outcomes for the primary, secondary, sensitivity and negative outcome analyses

From: Renin-angiotensin system inhibitors and susceptibility to COVID-19 in patients with hypertension: a propensity score-matched cohort study in primary care

  Primary Analysis Sensitivity Analysis Primary Analysis Sensitivity Analysis
ACE-I CCB ACE-I
+/− CCB
CCB ARB CCB ARB
+/− CCB
CCB
Suspected or confirmed COVID-19
Propensity score matched analysis
  Outcome events, n (%) 83 (0.44) 85 (0.45) 108 (0.45) 108 (0.45) 79 (0.74) 58 (0.55) 88 (0.66) 75 (0.57)
  Person-years 8923 8932 11,211 11,219 5010 5016 6258 6267
  Crude incidence rate/1000 person-years 9.30 9.52 9.63 9.63 15.77 11.56 14.06 11.97
  Unadjusted incidence rate ratio (95% CI) 0.98 (0.72–1.32) p = 0.885 1.00 (0.77–1.31) p = 0.994 1.36 (0.97–1.91) p = 0.072 1.18 (0.86–1.60) p = 0.304
  Adjusted hazard ratio (95% CI) 0.92 (0.68–1.26) p = 0.609 0.95 (0.72–1.24) p = 0.703 1.38 (0.98–1.95) p = 0.062 1.18 (0.86–1.61) p = 0.303
All-cause mortality
Propensity score matched Analysis
  Outcome events, n (%) 102 (0.54) 66 (0.35) 131 (0.55) 109 (0.46) 40 (0.38) 50 (0.47) 55 (0.41) 70 (0.53)
  Person-years 8941 8950 11,234 11,242 5028 5028 6278 6282
  Crude incidence rate/1000 person years 11.41 7.37 11.66 9.70 7.96 9.94 8.76 11.14
  Unadjusted incidence rate ratio (95% CI) 1.55 (1.14–2.11) p = 0.006 1.20 (0.93–1.55) p = 0.155 0.80 (0.53–1.21) p = 0.293 0.79 (0.55–1.12) p = 0.182
  Adjusted hazard ratio (95% CI) 1.25 (0.90–1.73) p = 0.182 1.00 (0.77–1.30) p = 0.977 0.85 (0.56–1.30) p = 0.458 0.76 (0.53–1.09) p = 0.138
Negative Control Outcome (Trauma/Accidents/Injury)
PS Matched Analysis
  Outcome events, n (%) 185 (0.98) 187 (0.99) 246 (1.04) 246 (1.04) 105 (0.99) 108 (1.02) 137 (1.03) 146 (1.10)
  Person-years 8898 8904 11,176 11,182 5004 5002 6245 6246
  Crude incidence rate/1000 person years 20.79 21.00 22.01 22.00 20.98 21.59 21.94 23.37
  Unadjusted incidence rate ratio (95% CI) 0.99 (0.81–1.21) p = 0.923 1.00 (0.84–1.19) p = 0.996 0.97 (0.74–1.27) p = 0.835 0.94 (0.74–1.18) p = 0.594
  Adjusted hazard ratio (95% CI) 0.95 (0.77–1.17) p = 0.640 0.96 (0.80–1.14) p = 0.620 0.97 (0.74–1.27) p = 0.801 0.91 (0.72–1.15) p = 0.439
  1. ACE-I angiotensin converting enzyme inhibitor, ARB angiotensin II receptor blocker, CCB calcium channel blocker