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Table 2 Aetiology obtained from blood- and valve culture among patients with IDU-IE and non-IDU-IE

From: Patients with infective endocarditis and history of injection drug use in a Swedish referral hospital during 10 years

  IDU-IE Non-IDU-IE P value
Blood culture resultsa (n (%)) 144 (87) 336 (94) <  0.01
Staphylococcus aureus (MSSA) 110 (67) 116 (32) <  0.01
Enterococcus faecalis 14 (8) 34 (10) 0.70
Viridans group streptococci 9 (5) 94 (26) <  0.01
S. aureus (MRSA) 3 (2) 3 (1) 0.39
Bacillus cereus 3 (2) 0 (0)
CoNS 2 (1) 22 (6) 0.01
Group A streptococci 1 (1) 1 (0) 0.53
Group B streptococci 0 (0 11 (3)
Group G streptococci 1 (1) 6 (2) 0.44
Klebsiella spp 1 (1) 0 (0)
Candida spp. 0 (0) 1 (0)
Unspecified funghi 1 (1) 1 (0) 0.53
Polymicrobial blood cultures 11 (7) 7 (2) <  0.01
MSSA and E. faecalis 4 (2) 0 (0)
E. faecalis and unspecified funghi 1 (1) 0 (0)
MSSA and aerobic gramnegative stave 1 (1) 0 (0)
MSSA and candida 1 (1) 0 (0)
MSSA and group G streptococci 1 (1) 0 (0)
MSSA and unspecified funghi 1 (1) 0 (0)
MSSA and viridans group streptococci 1 (1) 1 (0) 0.53
Viridans group streptococci and CoNS 1 (1) 0 (0)
Blood culture negative 8 (5) 19 (5) 0.82
Bacteria in valve culture from cardiac surgery 9 (5) 17 (5) 0.73
Staphylococcus aureus (MSSA) 5 (3) 7 (2) 0.53
Unspecified funghi 2 (1) 1 (0)
CoNS 1 (1) 2 (1) 1.00
Enterococcus faecalis 1 (1) 2 (1) 1.00
  1. a Single bacteria in blood culture. All patients in the IDU-IE group with positive valve culture had positive blood culture. Two of the patients in the non-IDU-IE group with positive valve culture had negative blood cultures. Of the patients with positive valve culture in the IDU-IE group, one had bacteria that differed between blood culture (MSSA) and valve culture (unspecified funghi). Of the patients with positive valve culture in the non-IDU-IE group, one had bacteria that differed between blood culture (MSSA) and valve culture (viridans group streptococci). Abbreviations: CoNS coagulase negative staphylococci; E enterococcus; IDU injection drug use; IE infective endocarditis; MRSA methicillin resistant Staphylococcus aureus; MSSA methicillin susceptible Staphylococcus aureus; n number of patients; PCR polymerase chain reaction; S staphylococcus; spp. species