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Table 3 MDR status of Index Cases from routine and study sputum specimens. Detailed results for rifampicin (RIF) and isoniazid (INH) are provided on the left with combined MDR status on the right

From: Drug susceptibility patterns of Mycobacterium tuberculosis from adults with multidrug-resistant tuberculosis and implications for a household contact preventive therapy trial

Rifampicin Resistance

Isoniazid Resistance

Routine n

Study n

MDR statusa

Routine

Study

n

% of 308

n

% of 280

R: Hain

R: Hain

86

 

MDR

232

75.3

55

19.6

R: Hain

Discord: Hain S, Pheno R

1

 

R: Hain & Pheno

R: Hain & Pheno

32

 

R: Hain & Pheno

Discord: Hain S, Pheno R

1

 

R: Pheno

R: Pheno

28

3

R: Xpert

R: Pheno

 

1

R: Xpert & Hain

R: Hain

46

8

R: Xpert & Hain

Discord: Hain S, Pheno R

2

 

R: Xpert & Pheno

R: Pheno

12

35

R: Xpert, Hain, & Pheno

R: Hain & Pheno

21

6

R: Xpert, Hain, & Pheno

Discord: Hain S, Pheno R

1

 

Discord: Hain S, Pheno R

Discord: Hain S, Pheno R

1

 

Discord: Xpert R, Pheno R and Sb

Discord: Pheno R and Sb

 

1

Discord: Xpert R, Pheno Sc

R: Pheno

 

1

Discord: Xpert S, Pheno R

R: Pheno

1

 

R: Hain

I: Hain

1

 

RIF R, INH not R

13

4.2

6

2.1

R: Xpert & Hain

I: Hain

 

1

Discord: Xpert R, Hain I

I: Hain

 

1

Discord: Xpert R, Hain S

I: Hain

 

1

R: Xpert & Hain

S: Hain

11

2

Discord: Xpert R, Hain S

S: Hain

1

1

R: Hain

(no results)

7

 

RIF R, INH no results

62

20.1

63

22.5

R: Xpert

(no results)

51

63

R: Xpert & Pheno

(no results)

3

 

Discord: Xpert S, Pheno R

(no results)

1

 

R: Pheno

S: Pheno

1

 

Mono-R to RIF(S to INH)

1

0.3

4

1.4

R: Xpert & Pheno

S: Pheno

 

2

Discord: Xpert R, Pheno Sc

S: Pheno

 

2

S: Xpert & Pheno

R: Pheno

 

2

Mono-R to INH(S to RIF)

  

2

0.7

S: Hain

S: Hain

 

1

RIF not R, INH not R

  

2

0.7

Discord: Xpert I, Pheno S

S: Pheno

 

1

I: Xpert

(no results)

 

1

RIF not R, INH no results

  

13

4.6

S: Xpert

(no results)

 

12

(no results)

(no results)

 

135

No results

  

135

48.2

TOTAL

 

308

280

 

308

100.0

280

100.0

  1. R Resistant; S = Susceptible, I Indeterminate, Discord Discordant results
  2. Hain resistance detected by Hain, Pheno resistance detected phenotypically, Xpert resistance detected by Xpert
  3. aClassified as resistant (R) if resistance reported by any method. If not resistant, noted as “not R”
  4. bPheno R and S: Indirect proportion R, MGIT S
  5. cXpert R, Pheno S by MGIT: could be disputed rpoB mutations