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Table 1 Smear, Xpert MTB/RIF, Hain MTBDRplus and culture results for MDR-TB index cases from routine and study sputum specimens

From: Drug susceptibility patterns of Mycobacterium tuberculosis from adults with multidrug-resistant tuberculosis and implications for a household contact preventive therapy trial

 

Routine sputum used by TB program for MDR-TB diagnosis (combined specimens per index case)

Study sputum collected on MDR-TB treatment (one specimen per index case)

n

% of done

% of 308

n

% of done

% of 280

Smear donea

217

70.5

280

100.0

 Smear positive

149

68.7

48.4

94

33.6

33.6

  Smear 3+

57

26.3

18.5

20

7.1

7.1

  Smear 2+

39

18.0

12.7

18

6.4

6.4

  Smear 1+

41

18.9

13.3

19

6.8

6.8

  Smear scanty

12

5.5

3.9

37

13.2

13.2

  Smear negative

68

31.3

22.1

186

66.4

66.4

Xpert done

152

49.4

278

99.3

 Xpert MTB+

150

98.7

48.7

141

50.7

50.4

 Xpert MTB not detected

1

0.7

0.3

135

48.6

48.2

 Xpert no result

1

0.7

0.3

2

0.7

0.7

Hain MTBDRplus done

214

69.5

27

9.6

 Hain MTBDRplus MTB+

211

98.6

68.5

21

77.8

7.5

 Hain MTBDRplus MTB not detected

2

0.9

0.6

6

22.2

2.1

 Hain MTBDRplus indeterminate

1

0.5

0.3

   

Liquid culture done

159

51.6

274

97.9

 Liquid culture MTB+

147

92.5

47.7

82

29.9

29.3

 Liquid culture NTM+

   

3

1.1

1.1

 Liquid culture negative

8

5.0

2.6

168

61.3

60.0

 Liquid culture contaminated

4

2.5

1.3

21

7.7

7.5

Solid culture done

64

20.8

58

20.7

 Solid culture MTB+

57

89.1

18.5

14

24.1

5.0

 Solid culture negative

5

7.8

1.6

43

74.1

15.4

 Solid culture contaminated

2

3.1

0.6

1

1.7

0.4

Liquid or solid culture done

193

62.7

275

98.2

 Liquid or solid culture MTB+

179

92.7

58.1

85

30.9

30.4

 Liquid or solid culture negative

9

4.7

2.9

172

62.5

61.4

 Liquid or solid culture contaminated

5

2.6

1.6

18

6.5

6.4

 Any Xpert or Hain or culture done

308

100.0

280

100.0

 Any Xpert or Hain or culture MTB+

308

100.0

100.0

147

52.5

52.5

  1. MTB+ M.tuberculosis complex detected or positive, NTM nontuberculous mycobacteria
  2. aSmear microscopy using GLI-WHO-IUATLD grading scale [4], smear positive includes scanty, 1+, 2+, and 3+