Table 1 Assessment of additional potential SARS-CoV-2 infections using loss of smell/taste and Oxford ELISA readings (n = 9324 samples) and Abbott CMIA readings (n = 11,342). The previously reported sensitivity of the Oxford ELISA is 99.1% (95%CI 97.8–99.7%) and the Abbott CMIA is 92.7% (90.2–94.8%) [8]
From: Stringent thresholds in SARS-CoV-2 IgG assays lead to under-detection of mild infections
Oxford ELISA reading | |||
< 4 million Low negative | 4.0–7.9 million High negative | ≥8 million Positive | |
Loss of smell/taste reported | 326 (4.1%) | 59 (13.1%) | 426 (47.0%) |
Loss of smell/taste not reported | 7643 (95.9%) | 390 (86.9%) | 480 (53.0%) |
Total | 7969 | 449 | 906 |
Additional estimated number with loss of smell/taste above baseline | – | 40 (9.0%) | 389 (42.9%) |
Abbott CMIA reading | |||
< 0.2 Low negative | 0.2–1.39 High negative | ≥1.4 Positive | |
Loss of smell/taste reported | 358 (3.7%) | 106 (15.5%) | 518 (47.4%) |
Loss of smell/taste not reported | 9205 (96.3%) | 580 (84.5%) | 575 (52.6%) |
Total | 9563 | 686 | 1093 |
Additional estimated number with loss of smell/taste above baseline | – | 81 (11.8%) | 478 (43.7%) |