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Table 3 Possible risk factors associated with mortality among CM patients with DM II

From: The clinical profiles and outcomes of HIV-negative cryptococcal meningitis patients in type II diabetes mellitus

Variables

Surviving patients (N = 20)

Dead patients (N = 6)

P value

Age (years)

57.95 ± 15.38

55.75 ± 10.61

0.533

Sex: Male (n %)

9 (45.00%)

3 (50.00%)

0.829

Duration before confirmed diagnosis (days)

29.85 ± 22.80

17.83 ± 11.05

0.355

Duration of DM II course (years)

4.27 ± 3.67

4.00 ± 2.19

0.882

Poor DM II management (n %)

6 (30.00%)

4 (66.67%)

0.105

Underlying diseases (n %)

11 (55.00%)

4 (66.67%)

0.612

Clinical parameters

 Fever (n %)

15 (75.00%)

6 (100%)

0.671

 Headache (n %)

19 (73.08%)

6 (100%)

0.419

 Nausea/Vomiting (n %)

10 (50.00%)

6 (100%)

0.027*

 Vision disorders (n %)

3 (15.00%)

1 (16.67%)

0.921

 Auditory symptoms (n %)

3 (15.00%)

1 (16.67%)

0.921

 Seizure (n %)

2 (10.00%)

1 (16.67%)

0.654

 Conscious disturbance (n %)

5 (25.00%)

3 (50.00%)

0.245

CSF examinations

 Opening pressure (mmH2O)

258.00 ± 99.92

316.67 ± 98.20

0.295

 CSF protein (mg/l)

983.35 ± 641.03

1175.20 ± 411.96

0.268

 CSF glucose (mmol/l)

2.38 ± 1.13

1.95 ± 0.40

0.882

 Brain images abnormalitya (n %)

13 (65.00%)

5 (83.33%)

0.393

  1. Abbreviations: CM cryptococcal meningitis, DM II type II diabetes mellitus, CSF cerebrospinal fluid
  2. aBrain image abnormalities included meningeal enhancement, hydrocephalus, cerebral infarction and so on
  3. *p < 0.05