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Table 4 Characteristics of the included studies for AUC and trough-guided monitoring

From: The monitoring of vancomycin: a systematic review and meta-analyses of area under the concentration-time curve-guided dosing and trough-guided dosing

Study Design of study Country Duration of study Age of patients Number of patients Target AUC (mg*hr./L) Target trough (mg/L) Rate (%) of MRSA
AUC-guided Trough-guided
Finch 2017 [47] Retrospective, quasi-experimental study America 2014–2015 ≥ 18
Mean ± SD: 59.1 ± 16.9
734 546 400–600 15–20 N/A
Neely 2018 [48] 3-year, prospective, serial cohort study America 2012–2016 ≥ 18
Mean (range): 48.7 (18–93)
177 75 400–800 10–20 10
Meng 2019 [15] Prospective observational quality assurance study America 2017–2018 ≥ 18
Median ± SD (IQR):
Trough-guided 58 ± 17 (46–67)
AUC-guided 62 ± 17 (46–68)
117 179 400–800 10–20 9
Oda 2020 [49] Single-centered retrospective study Japan 2016–2020 ≥ 19
Median (range):
Trough-guided 68.5 (19–84)
AUC-guided 64.0 (19–87)
22 52 400–600 15–20 36
  1. N/A not available
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