Fig. 5

Forest plot of treatment failure and risk of nephrotoxicity associated with VCM AUC/MIC ratio and AUC value. The vertical line indicates no significant difference between the groups compared Diamond shapes and horizontal lines represent ORs and 95% CIs, respectively. Squares indicate point estimates, and the size of each square indicates the weight of each study included in this meta-analysis. a The OR of treatment failure associated with AUC/MIC ratios restricted with 400 ± 15% (392.7–451). b The OR of risk of nephrotoxicity associated with AUC values restricted with 600 ± 15% (550–683)