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Table 3 Association between CT findings and laboratory data (corrected for parenchymal extension)

From: The association between clinical laboratory data and chest CT findings explains disease severity in a large Italian cohort of COVID-19 patients

  Ground-glass opacities Consolidation Crazy paving
  N (n = 29) Y (=837) P*/P** N (n = 319) Y (n = 547) P*/P** N (n = 126) Y (n = 191) P*/P**
White blood cells (10^9/L) 5.77 (3.84–7.10) (n = 26) 5.10 (4.02–6.51) (n = 772) 0.5890/0.1833 5.00 (3.98–6.34) (n = 285) 5.15 (4.02–6.60) (n = 513) 0.1979/0.5441 5.11 (3.99–6.57) (n = 110) 5.29 (4.16–6.63) (n = 173) 0.5099/0.7682
Neutrophils (10^9/L) 3.52 (2.71–4.67) (n = 24) 3.56 (2.58–4.72) (n = 695) 0.7394/0.4439 3.42 (2.60–4.63) (n = 252) 3.61 (2.56–4.80) (n = 467) 0.1437/0.5918 3.57 (2.66–4.71) (n = 89) 4.06 (2.71–5.33) (n = 154) 0.4268/0.8354
Lymphocytes (10^9/L) 1.47 (0.81–1.93) (n = 24) 1.04 (0.77–1.40) (n = 692) 0.0887/0.3354 1.08 (0.82–1.46) (n = 252) 1.02 (0.75–1.39) (n = 464) 0.2403/0.5464 1.00 (0.72–1.31) (n = 89) 0.94 (0.69–1.34) (n = 152) 0.7478/0.2758
Platelets (10^9/L) 205.00 (159.50–267.75) (n = 25) 180.00 (145.12–222.19) (n = 767) 0.0422/0.0201 174.72 (149.00–221.75) (n = 283) 184.00 (144.00–223.61) (n = 509) 0.7304/0.9761 178.00 (142.75–212.25) (n = 109) 174.00 (139.50–222.19) (n = 175) 0.1109/0.3102
Prothrombin time (ratio) 0.95 (0.95–0.95) (n = 1) 1.08 (1.00–1.14) (n = 145) 0.3795/0.4951 1.09 (1.03–1.12) (n = 32) 1.07 (1.00–1.16) (n = 114) 0.5081/0.4801 1.04 (0.98–1.12) (n = 49) 1.09 (1.02–1.17) (n = 96) 0.8513/0.5647
C-reactive protein (mg/L) 7.05 (1.30–29.90) (n = 26) 34.45 (14.90–82.80) (n = 764) 0.0197/0.7841 23.80 (9.92–53.42) (n = 281) 43.60 (17.25–96.04) (n = 509) < 0.0001/< 0.0001 37.50 (14.10–80.96) (n = 107) 74.70 (29.23–126.95) (n = 171) 0.0065/0.6653
Procalcitonin (μg/L) 0.09 (0.05–0.15) (n = 12) 0.12 (0.08–0.25) (n = 195) 0.0416/0.0245 0.10 (0.05–0.19) (n = 56) 0.13 (0.09–0.28) (n = 151) 0.7360/0.6694 0.11 (0.07–0.25) (n = 66) 0.14 (0.09–0.25) (n = 125) 0.8514/0.9498
Creatinine (μmol/L) 75.16 (60.39–92.40) (n = 13) 83.82 (69.41–98.94) (n = 278) 0.6436/0.8846 84.88 (65.61–95.76) (n = 79) 84.88 (71.53–99.03) (n = 212) 0.3396/0.4231 82.23 (68.08–96.82) (n = 104) 84.00 (71.09–102.57) (n = 172) 0.1572/0.0468
AST (U/L) 28.00 (21.50–35.25) (n = 11) 38.76 (28.00–50.00) (n = 234) 0.0709/0.5098 38.00 (27.00–49.00) (n = 73) 38.00 (28.40–50.00) (n = 172) 0.6819/0.9841 31.00 (24.00–44.25) (n = 85) 40.34 (30.96–52.00) (n = 146) 0.0061/0.0698
ALT (U/L) 25.00 (19.00–36.50) (n = 11) 29.00 (20.00–41.34) (n = 239) 0.2297/0.5579 29.83 (22.00–44.00) (n = 74) 28.00 (19.00–40.00) (n = 176) 0.4871/0.3426 27.00 (19.00–38.00) (n = 87) 29.00 (21.07–43.00) (n = 148) 0.0422/0.1239
Total bilirubin (μmol/L) 9.41 (8.55–13.68) (n = 10) 10.26 (7.39–13.68) (n = 220) 0.9687/0.8017 8.55 (6.84–11.97) (n = 69) 10.26 (8.55–13.77) (n = 161) 0.1239/0.1136 9.41 (7.46–11.97) (n = 81) 10.26 (8.11–13.68) (n = 135) 0.2978/0.2033
Albumin (g/L) (n = 0) 38.35 (35.90–40.70) (n = 82) ND 38.15 (36.75–41.45) (n = 16) 38.50 (35.70–40.40) (n = 66) 0.3277/0.3778 38.90 (36.20–40.55) (n = 32) 38.00 (35.55–40.55) (n = 49) 0.7033/0.3991
LDH (U/L) 376.00 (354.25–471.50) (n = 23) 490.00 (390.65–619.75) (n = 635) 0.0413/0.4449 459.00 (379.00–565.00) (n = 245) 502.00 (394.78–644.00) (n = 413) 0.0039/0.0821 469.00 (379.50–596.00) (n = 68) 572.00 (449.71–724.00) (n = 116) 0.0063/0.6203
PCO2 (mmHg) 40.05 (30.90–45.95) (n = 8) 34.60 (31.50–37.58) (n = 235) 0.0580/0.0781 35.80 (31.70–38.65) (n = 72) 34.30 (31.10–37.50) (n = 171) 0.6043/0.6623 34.25 (30.90–37.70) (n = 82) 34.90 (31.50–37.58) (n = 147) 0.7452/0.8746
PO2 (mmHg) 76.70 (72.35–87.15) (n = 8) 70.65 (63.50–80.60) (n = 234) 0.6333/0.8540 73.15 (65.60–83.70) (n = 72) 69.50 (62.40–80.00) (n = 170) 0.3262/0.5264 74.35 (65.30–84.80) (n = 82) 68.05 (62.20–77.30) (n = 146) 0.0034/0.0396
sO2 (%) 96.90 (94.55–98.30) (n = 23) 95.40 (93.50–96.80) (n = 712) 0.1516/0.6693 95.80 (94.03–97.10) (n = 275) 95.20 (93.15–96.70) (n = 460) 0.0005/0.0154 95.55 (93.40–96.90) (n = 90) 93.85 (91.70–95.70) (n = 150) 0.0203/0.3603
  1. Data are reported as median (interquartile range). P: p-value for coefficient of CT variable in a multiple linear regression controlled for confounders age and sex (P*) or age, sex and CT extension (P**). P-values for predictor CT extension in these models were < 0.05 for total leukocytes, neutrophils, platelets, CRP, creatinine, AST, ALT, LDH, albumin and oxygen partial pressure and saturation
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