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Table 3 Association between CT findings and laboratory data (corrected for parenchymal extension)

From: The association between clinical laboratory data and chest CT findings explains disease severity in a large Italian cohort of COVID-19 patients

 

Ground-glass opacities

Consolidation

Crazy paving

 

N (n = 29)

Y (=837)

P*/P**

N (n = 319)

Y (n = 547)

P*/P**

N (n = 126)

Y (n = 191)

P*/P**

White blood cells (10^9/L)

5.77 (3.84–7.10) (n = 26)

5.10 (4.02–6.51) (n = 772)

0.5890/0.1833

5.00 (3.98–6.34) (n = 285)

5.15 (4.02–6.60) (n = 513)

0.1979/0.5441

5.11 (3.99–6.57) (n = 110)

5.29 (4.16–6.63) (n = 173)

0.5099/0.7682

Neutrophils (10^9/L)

3.52 (2.71–4.67) (n = 24)

3.56 (2.58–4.72) (n = 695)

0.7394/0.4439

3.42 (2.60–4.63) (n = 252)

3.61 (2.56–4.80) (n = 467)

0.1437/0.5918

3.57 (2.66–4.71) (n = 89)

4.06 (2.71–5.33) (n = 154)

0.4268/0.8354

Lymphocytes (10^9/L)

1.47 (0.81–1.93) (n = 24)

1.04 (0.77–1.40) (n = 692)

0.0887/0.3354

1.08 (0.82–1.46) (n = 252)

1.02 (0.75–1.39) (n = 464)

0.2403/0.5464

1.00 (0.72–1.31) (n = 89)

0.94 (0.69–1.34) (n = 152)

0.7478/0.2758

Platelets (10^9/L)

205.00 (159.50–267.75) (n = 25)

180.00 (145.12–222.19) (n = 767)

0.0422/0.0201

174.72 (149.00–221.75) (n = 283)

184.00 (144.00–223.61) (n = 509)

0.7304/0.9761

178.00 (142.75–212.25) (n = 109)

174.00 (139.50–222.19) (n = 175)

0.1109/0.3102

Prothrombin time (ratio)

0.95 (0.95–0.95) (n = 1)

1.08 (1.00–1.14) (n = 145)

0.3795/0.4951

1.09 (1.03–1.12) (n = 32)

1.07 (1.00–1.16) (n = 114)

0.5081/0.4801

1.04 (0.98–1.12) (n = 49)

1.09 (1.02–1.17) (n = 96)

0.8513/0.5647

C-reactive protein (mg/L)

7.05 (1.30–29.90) (n = 26)

34.45 (14.90–82.80) (n = 764)

0.0197/0.7841

23.80 (9.92–53.42) (n = 281)

43.60 (17.25–96.04) (n = 509)

< 0.0001/< 0.0001

37.50 (14.10–80.96) (n = 107)

74.70 (29.23–126.95) (n = 171)

0.0065/0.6653

Procalcitonin (μg/L)

0.09 (0.05–0.15) (n = 12)

0.12 (0.08–0.25) (n = 195)

0.0416/0.0245

0.10 (0.05–0.19) (n = 56)

0.13 (0.09–0.28) (n = 151)

0.7360/0.6694

0.11 (0.07–0.25) (n = 66)

0.14 (0.09–0.25) (n = 125)

0.8514/0.9498

Creatinine (μmol/L)

75.16 (60.39–92.40) (n = 13)

83.82 (69.41–98.94) (n = 278)

0.6436/0.8846

84.88 (65.61–95.76) (n = 79)

84.88 (71.53–99.03) (n = 212)

0.3396/0.4231

82.23 (68.08–96.82) (n = 104)

84.00 (71.09–102.57) (n = 172)

0.1572/0.0468

AST (U/L)

28.00 (21.50–35.25) (n = 11)

38.76 (28.00–50.00) (n = 234)

0.0709/0.5098

38.00 (27.00–49.00) (n = 73)

38.00 (28.40–50.00) (n = 172)

0.6819/0.9841

31.00 (24.00–44.25) (n = 85)

40.34 (30.96–52.00) (n = 146)

0.0061/0.0698

ALT (U/L)

25.00 (19.00–36.50) (n = 11)

29.00 (20.00–41.34) (n = 239)

0.2297/0.5579

29.83 (22.00–44.00) (n = 74)

28.00 (19.00–40.00) (n = 176)

0.4871/0.3426

27.00 (19.00–38.00) (n = 87)

29.00 (21.07–43.00) (n = 148)

0.0422/0.1239

Total bilirubin (μmol/L)

9.41 (8.55–13.68) (n = 10)

10.26 (7.39–13.68) (n = 220)

0.9687/0.8017

8.55 (6.84–11.97) (n = 69)

10.26 (8.55–13.77) (n = 161)

0.1239/0.1136

9.41 (7.46–11.97) (n = 81)

10.26 (8.11–13.68) (n = 135)

0.2978/0.2033

Albumin (g/L)

(n = 0)

38.35 (35.90–40.70) (n = 82)

ND

38.15 (36.75–41.45) (n = 16)

38.50 (35.70–40.40) (n = 66)

0.3277/0.3778

38.90 (36.20–40.55) (n = 32)

38.00 (35.55–40.55) (n = 49)

0.7033/0.3991

LDH (U/L)

376.00 (354.25–471.50) (n = 23)

490.00 (390.65–619.75) (n = 635)

0.0413/0.4449

459.00 (379.00–565.00) (n = 245)

502.00 (394.78–644.00) (n = 413)

0.0039/0.0821

469.00 (379.50–596.00) (n = 68)

572.00 (449.71–724.00) (n = 116)

0.0063/0.6203

PCO2 (mmHg)

40.05 (30.90–45.95) (n = 8)

34.60 (31.50–37.58) (n = 235)

0.0580/0.0781

35.80 (31.70–38.65) (n = 72)

34.30 (31.10–37.50) (n = 171)

0.6043/0.6623

34.25 (30.90–37.70) (n = 82)

34.90 (31.50–37.58) (n = 147)

0.7452/0.8746

PO2 (mmHg)

76.70 (72.35–87.15) (n = 8)

70.65 (63.50–80.60) (n = 234)

0.6333/0.8540

73.15 (65.60–83.70) (n = 72)

69.50 (62.40–80.00) (n = 170)

0.3262/0.5264

74.35 (65.30–84.80) (n = 82)

68.05 (62.20–77.30) (n = 146)

0.0034/0.0396

sO2 (%)

96.90 (94.55–98.30) (n = 23)

95.40 (93.50–96.80) (n = 712)

0.1516/0.6693

95.80 (94.03–97.10) (n = 275)

95.20 (93.15–96.70) (n = 460)

0.0005/0.0154

95.55 (93.40–96.90) (n = 90)

93.85 (91.70–95.70) (n = 150)

0.0203/0.3603

  1. Data are reported as median (interquartile range). P: p-value for coefficient of CT variable in a multiple linear regression controlled for confounders age and sex (P*) or age, sex and CT extension (P**). P-values for predictor CT extension in these models were < 0.05 for total leukocytes, neutrophils, platelets, CRP, creatinine, AST, ALT, LDH, albumin and oxygen partial pressure and saturation