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Table 2 Association between parenchymal CT extension and laboratory data

From: The association between clinical laboratory data and chest CT findings explains disease severity in a large Italian cohort of COVID-19 patients

  CT lesion extension  
  < 20% (n = 339) 20–40% (n = 340) 40–60% (n = 120) > 60% (n = 67)  
  N Median (IQR) N Median (IQR) N Median (IQR) N Median (IQR) P
White blood cells (10^9/L) 304 4.79 (3.84–5.91) 315 5.11 (4.02–6.50) 113 5.60 (4.33–7.85) 66 6.22 (4.66–7.97) 0.0005
Neutrophils (10^9/L) 265 3.02 (2.32–4.04) 291 3.64 (2.66–4.76) 101 4.13 (3.05–6.16) 62 4.79 (3.49–6.49) < 0.0001
Lymphocytes (10^9/L) 264 1.14 (0.86–1.57) 290 1.05 (0.77–1.39) 100 0.89 (0.68–1.29) 62 0.85 (0.63–1.05) 0.0004
Platelets (10^9/L) 301 180.00 (146.51–221.25) 313 176.00 (147.29–218.75) 113 180.00 (140.19–218.25) 65 214.00 (159.00–269.25) 0.0086
Prothrombin time (ratio) 29 1.00 (0.96–1.05) 55 1.10 (1.02–1.15) 37 1.08 (1.02–1.19) 25 1.10 (1.05–1.14) 0.1367
C-reactive protein (mg/L) 299 15.00 (7.02–29.73) 315 43.02 (24.03–85.38) 112 84.60 (46.68–135.66) 64 122.50 (49.55–206.40) < 0.0001
Procalcitonin (μg/L) 59 0.090 (0.05–0.12) 75 0.13 (0.09–0.20) 46 0.18 (0.11–0.41) 27 0.26 (0.11–0.60) 0.6363
Creatinine (μmol/L) 90 75.60 (67.20–91.96) 109 84.88 (67.91–95.67) 59 88.42 (74.36–114.95) 33 92.84 (79.14–128.21) 0.0162
AST (U/L) 68 28.50 (23.20–36.00) 90 38.50 (29.00–49.00) 58 43.00 (34.00–62.28) 29 45.00 (40.00–52.95) < 0.0001
ALT (U/L) 71 25.00 (19.25–39.50) 93 30.73 (19.00–43.50) 57 32.00 (23.54–41.11) 29 30.00 (23.22–39.50) 0.0091
Total bilirubin (μmol/L) 63 8.55 (6.84–11.97) 86 10.26 (8.48–13.68) 51 10.26 (6.84–13.68) 30 11.12 (8.55–17.10) 0.9055
Albumin (g/L) 14 40.90 (38.30–42.20) 30 38.60 (36.30–41.20) 25 37.50 (35.55–39.52) 13 38.30 (32.63–40.10) 0.0077
LDH (U/L) 249 408.50 (358.15–487.00) 273 510.53 (422.77–599.75) 88 639.50 (474.85–783.50) 49 707.00 (496.81–896.50) < 0.0001
PCO2 (mmHg) 73 35.70 (32.58–38.35) 86 34.40 (31.00–37.20) 53 33.30 (30.88–36.45) 31 36.30 (32.15–42.08) 0.6574
PO2 (mmHg) 73 79.50 (69.33–87.05) 85 71.00 (64.20–78.40) 53 65.50 (61.68–74.42) 31 60.80 (54.63–72.65) 0.0014
SO2 (%) 284 96.50 (95.00–97.80) 286 95.20 (93.80–96.50) 103 93.70 (91.80–95.78) 62 91.80 (88.30–94.40) < 0.0001
  1. P: p-value for coefficient of CT variable in a multiple linear regression controlled for confounders age and sex
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