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Table 3 Factors associated with drug resistance transmission within clusters

From: HIV drug resistance and HIV transmission risk factors among newly diagnosed individuals in Southwest China

Variables N Persons in TC DR in TC Crude OR (95% CI) p Adjusted OR (95% CI)a p
Age
  < 35 years 508 (44.14) 288 (56.7) 7 (1.4) 1   1  
  ≥ 35 years 643 (55.86) 297 (46.2) 29 (4.5) 4.34 (1.87–10.08) 0.001 3.02 (0.94–9.73) 0.064
Marital status
 Married 479 (41.62) 221 (46.1) 17 (3.5) 1   1  
 Unmarried 534 (46.39) 305 (57.1) 13 (2.4) 0.57 (0.28–1.19) 0.133 4.24 (1.51–11.9) 0.006
 Divorced/widowed 126 (10.95) 50 (39.7) 3 (2.4) 0.77 (0.22–2.72) 0.680   
 Unknown 12 (1.04) 9 (75.0) 2 (16.7) 6.0 (1.02–35.16) 0.047 6.26 (0.8–49.3) 0.081
Educational level
 College and above 336 (29.19) 203 (60.4) 3 (0.9) 1   1  
 High school/ technical school 225 (19.55) 118 (52.4) 2 (0.9) 0.16 (0.04–0.69) 0.88 1.29 (0.2–8.39) 0.793
 Junior high school/ below 590 (51.3) 264 (44.7) 31 (5.3) 8.87 (2.67–29.45) 0.000 5.89 (1.37–24.97) 0.017
Ethnicity
 Han 601 (52.22) 311 (51.7) 16 (2.7) 1    
 Zhuang 483 (41.96) 235 (48.7) 16 (3.3) 1.35 (0.66–2.76) 0.409   
 Other 68 (5.91) 38 (55.9) 4 (5.9) 2.18 (0.69--6.89) 0.186   
Infection route
 Heterosexual 693 (60.21) 333 (48.1) 32 (4.6) 1   1  
 MSM 405 (35.19) 238 (58.8) 4 (1.0) 6.22 (2.17–17.83) 0.001 1.89 (0.51–6.99) 0.339
 Other 53 (4.60) 14 (26.4) 0 (0.0)    
Sex
 Male 919 (79.84) 490 (53.3) 28 (3.0) 1    
 Female 232 (20.16) 95 (40.9) 8 (3.4) 1.52 (0.67–3.44) 0.318   
Subtype
 CRF01_AE 485 (42.14) 226 (46.6) 12 (2.5) 1   1  
 CRF07_BC 356 (30.93) 218 (61.2) 6 (1.7) 0.51 (0.19–1.37) 0.179   
 CRF08_BC 183 (15.90) 81 (44.3) 17 (9.3) 4.74 (2.15–10.44) 0.000 3.69 (1.5–9.04) 0.004
 CRF55_01B 79 (6.86) 47 (59.5) 0 (0.0)    
 Other 48 (4.17) 13 (27.1) 1 (2.1) 1.49 (0.18–12.4) 0.714   
Year of Diagnosis
 2016 348 (30.23) 168 (48.3) 12 (3.4) 1    
 2017 422 (36.66) 232 (55.0) 16 (3.8) 0.96 (0.44–2.09) 0.924   
 2018 381 (33.1) 185 (48.6) 8 (2.1) 0.59 (0.23–1.48) 0.257   
  1. aAdjusted for age, marital status, educational level, subtype
  2. TC transmission clusters, DR drug resistance, OR odds ratio, CI confidence interval, MSM men who have sex with men, CRF circulating recombinant form