Point-of-care p24 antigen detection for early infant diagnosis of HIV infection: cross-sectional and longitudinal studies in Zambia

Table 1 Description of NSEBA study sites in Southern Province, Zambia, 2016–2018

Study site	Area	Type of area	Study period (mm/yy)	Median (range) deliveries per week by women living with HIV	Median (range) DBS collected per week for EID	Eligible participants	Timing of follow-up	Staff trained to perform LYNX assay
Livingstone Central Hospital	Livingstone City	Urban	06/16–05/17 06/17–04/18	8 (1, 15)	N/A	All HEI High-risk HEI^a	Birth only	1 Research staff^c
Maramba UHC	Livingstone City	Urban	06/16–05/17 06/17–04/18	3 (0, 12)	N/A	All HEI High-risk HEI^a	Birth only	1 Research staff^c
Mahatma Gandhi UHC	Livingstone City	Urban	04/17–04/18	3 (0, 9)	N/A	High-risk HEI^a	Birth only	1 Research staff^c
Libuyu UHC	Livingstone City	Urban	04/17–04/18	1 (0, 5)	N/A	High-risk HEI^a	Birth only	1 Research staff^c
Choma General Hospital	Choma City	Urban	08/17–04/18	5 (2, 9)	N/A	High-risk HEI^a	Birth only	2 Nurses
Shampande UHC	Choma City	Urban	08/17–04/18	2 (0, 5)	N/A	High-risk HEI^a	Birth only	2 Nurses
Macha Hospital	Macha area	Rural	04/16–09/18	2 (0, 9)	3 (0, 11)	All HEI	Testing period^b	5 Counselors 6 Research staff^c
Mapanza RHC	Macha area	Rural	04/16–09/18	0 (0, 4)	1 (0, 7)	All HEI	Testing period^b	1 Clinical Officer 2 Nurses 1 Counselor
Moboola RHC	Macha area	Rural	04/16–09/18	0 (0, 3)	1 (0, 7)	All HEI	Testing period^b	2 Nurses 1 Counselor
Mangunza RHC	Macha area	Rural	04/16–09/18	0 (0, 3)	1 (0, 5)	All HEI	Testing period^b	1 Nurse 1 Counselor
Nalube RHC	Macha area	Rural	04/16–07/17	0 (0, 2)	0 (0, 3)	All HEI	Testing period^b	1 Nurse 1 Counselor

DBS Dried blood spots, EID Early infant diagnosis, HEI HIV-exposed infants, N/A Not applicable, RHC Rural health clinic, UHC Urban health center
^a High-risk defined as mothers receiving no antiretroviral drugs throughout pregnancy or starting to receive antiretroviral drugs during pregnancy to prevent mother-to-child transmission
^b Testing period includes any point of contact for early infant diagnosis testing from birth to post-weaning (e.g. birth, 6 weeks, 6 months, 12 months, 18 months, 24 months, post-weaning)
^c Research staff in Livingstone included 3 nurses; research staff in Macha included 1 nurse, 1 laboratory scientist, and 4 counselors by training

ISSN: 1471-2334